Trial reportEuropean journal of clinical nutrition2015
Vitamin D3 seems more appropriate than D2 to sustain adequate levels of 25OHD: a pharmacokinetic approach.
Trial report in European journal of clinical nutrition, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Comparison of the Effect of Daily Vitamin D2 and Vitamin D3 Supplementation on Serum 25-Hydroxyvitamin D Concentration (Total 25(OH)D, 25(OH)D2, and 25(OH)D3) and Importance of Body Mass Index: A Systematic Review and Meta-Analysis.Advances in nutrition (Bethesda, Md.) · 2024Pooled it
- Relative Efficacy of Vitamin DNutrients · 2021Pooled it
- Vitamin D supplementation for term breastfed infants to prevent vitamin D deficiency and improve bone health.The Cochrane database of systematic reviews · 2020Pooled it
- Guideline
- Model-based meta-analysis for comparing Vitamin D2 and D3 parent-metabolite pharmacokinetics.Journal of pharmacokinetics and pharmacodynamics · 2017Pooled it
- Effects of vitamin D supplementation during autumn and winter on blood biomarkers and physical performance in runners and non runners.Scientific reports · 2026Trial
- Assessing the impact of a mushroom-derived food ingredient on vitamin D levels in healthy volunteers.Journal of the International Society of Sports Nutrition · 2020Trial
- Randomized controlled trial of vitamin D supplementation in older people to optimize bone health.The American journal of clinical nutrition · 2019Trial
- Dietary Vitamin D2 Is Less Potent Than Vitamin D3 at Maintaining or Restoring Structure and Metabolism of Skeletal Muscle and Heart in Male Rats.Molecular nutrition & food research · 2026Article
- Feasibility, acceptability and validity of electronic adherence monitoring among adolescents in Zimbabwe: a mixed methods study.BMC global and public health · 2026Article
- Nutritional Support of Chronic Obstructive Pulmonary Disease.Nutrients · 2025Review
- Association of a dietary pattern related to serum vitamin D levels with metabolic syndrome risk among Korean adults: based on the Korean national health and nutrition examination survey.European journal of nutrition · 2024Article
- Pharmacokinetics of vitamin dosage forms: A complete overview.Food science & nutrition · 2024Review
- Maternal plasma vitamin D levels across pregnancy are not associated with neonatal birthweight: findings from an Australian cohort study of low-risk pregnant women.BMC pregnancy and childbirth · 2023Article
- Association Between Plasma Vitamin D2 and Type 2 Diabetes Mellitus.Frontiers in endocrinology · 2022Article
- Potential impact of the steroid hormone, vitamin D, on the vasculature.American heart journal · 2021Review
- Vitamin D, Depressive Symptoms, and Covid-19 Pandemic.Frontiers in neuroscience · 2021Article
- Validation and Determination of 25(OH) Vitamin D and 3-Epi25(OH)D3 in Breastmilk and Maternal- and Infant Plasma during Breastfeeding.Nutrients · 2020Article
- Vitamin D supplementation after the menopause.Therapeutic advances in endocrinology and metabolism · 2020Review
- Emerging Role of Vitamin D and its Associated Molecules in Pathways Related to Pathogenesis of Thrombosis.Biomolecules · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesThe superiority of cholecalciferol (D3) over ergocalciferol (D2) in sustaining serum 25-hydroxy vitamin D (25OHD) levels is controversial. To compare D2 with D3 we performed a single-blind, placebo-controlled randomized trial spanning 11 weeks. SUBJECTS/
methodsHealthy volunteers (n=33, aged 33.4±6 years) were divided into three groups (n=11, each): D2, D3 and placebo. Treatment started with a loading dose (100,000 IU) followed by 4800 IU/day (d) between d7 and d20 and follow-up until d77. Serum samples were obtained at baseline and at days 3, 7, 14, 21, 35, 49, 63 and 77.
resultsBaseline 25OHD values in the D2 group were lower than those in the D3 and placebo groups (P<0.01). Placebo 25OHD levels never changed. As after the loading dose both D2 and D3 groups had reached similar 25OHD levels, we tested equivalence of the area under the concentration × time curve (AUC) between d7 and d77. The AUC was 28.6% higher for D3 compared with D2, and both were higher with respect to placebo. At d77, D2 25OHD levels were higher than those at baseline, but similar to placebo; both were lower than D3 (P<0.04). According to raw data, the elimination half-life of 25OHD was 84 and 111 days under D2 and D3 supplementation, respectively; after subtracting the placebo values, the corresponding figures were 33 and 82 days.
conclusionsD2 and D3 were equally effective in elevating 25OHD levels after a loading dose. In the long term, D3 seems more appropriate for sustaining 25OHD, which could be relevant for classic and non-classic effects of vitamin D.
Indexed as
Identifiers
25782422What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.