ArticleAmerican journal of ophthalmology2015
Reduced Corneal Endothelial Cell Density in Patients With Dry Eye Disease.
Article in American journal of ophthalmology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- Pooled it
- Corneal endothelial layer changes in the meibomian gland dysfunction cases in comparison to healthy controls: a cross-sectional study.BMC ophthalmology · 2026Article
- Beyond the Cornea: Systemic Diseases and Their Impact on Endothelial Health-A Narrative Review.Journal of clinical medicine · 2026Review
- Article
- Factors Affecting the Density of Corneal Endothelial Cells Cultured from Donor Corneas.International journal of molecular sciences · 2024Article
- Corneal endothelial cell density and associated factors among adults at a regional referral hospital in Uganda: a cross-sectional study.BMC ophthalmology · 2024Article
- Swept-source optical coherence tomography in ocular surface diseases: anterior segment analysis repeatability and its limits.Frontiers in medicine · 2024Article
- Bibliometric and visual analysis of diabetic keratopathy research: trends, collaborations, and future directions.Frontiers in medicine · 2024Article
- Role of NADPH Oxidase 4 in Corneal Endothelial Cells Is Mediated by Endoplasmic Reticulum Stress and Autophagy.Antioxidants (Basel, Switzerland) · 2023Article
- Sex differences in the relationship between axial length and dry eye in elderly patients.Frontiers in medicine · 2023Article
- Clinical association between trace elements of tear and dry eye metrics.Scientific reports · 2022Article
- Corneal endothelial cell density and its correlation with birth weight, anthropometric parameters, and ocular biometric parameters in Chinese school children.BMC ophthalmology · 2022Article
- Evaluation of Ocular Surface after Cataract Surgery-A Prospective Study.Journal of clinical medicine · 2022Article
- Risk factors for fluctuations in corneal endothelial cell density (Review).Experimental and therapeutic medicine · 2022Review
- The Neuropeptide Alpha-Melanocyte-Stimulating Hormone Is Critical for Corneal Endothelial Cell Protection and Graft Survival after Transplantation.The American journal of pathology · 2022Article
- Vision through Healthy Aging Eyes.Vision (Basel, Switzerland) · 2021Review
- The Role of Neuropeptides in Pathogenesis of Dry Dye.Journal of clinical medicine · 2021Review
- Ocular Surface Changes Associated with Ophthalmic Surgery.Journal of clinical medicine · 2021Review
- Article
- Corneal thickness and endothelial morphology in Normal Thai eyes.BMC ophthalmology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
purposeTo evaluate corneal endothelial cell density (ECD) in patients with dry eye disease (DED) compared to an age-matched control group.
designCross-sectional, controlled study.
methodsThis study included 90 eyes of 45 patients with moderate to severe DED (aged 53.7 ± 9.8 years) and 30 eyes of 15 normal controls (aged 50.7 ± 9.8 years). All subjects had a complete ophthalmic evaluation including symptom assessment using the Ocular Surface Disease Index (OSDI) and corneal fluorescein staining. In addition, laser scanning in vivo confocal microscopy was performed to measure the density of the following parameters in the central cornea: endothelial cells, subbasal nerves, and subbasal immune dendritic cells.
resultsCorneal ECD was significantly lower in the DED group (2595.8 ± 356.1 cells/mm(2)) than in the control group (2812.7 ± 395.2 cells/mm(2), P = .046). The DED group showed significantly lower corneal subbasal nerve density (17.1 ± 6.9 mm/mm(2)) compared to the control group (24.7 ± 4.4 mm/mm(2), P < .001). Dendritic cell density was significantly higher in the DED group than in the controls (111.7 ± 137.3 vs 32.0 ± 24.4 cells/mm(2), respectively, P = .002). There were statistically significant correlations between corneal ECD and dry eye severity parameters including the OSDI score (rs = -0.26, P = .03), and corneal fluorescein staining (rs = -0.28, P = .008).
conclusionsThere is a significant reduction in corneal ECD in DED that correlates with clinical severity of the disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.