ArticleEnvironmental health perspectives2015
Measurement of Total and Free Urinary Phenol and Paraben Concentrations over the Course of Pregnancy: Assessing Reliability and Contamination of Specimens in the Norwegian Mother and Child Cohort Study.
Article in Environmental health perspectives, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Bisphenol A exposure and abnormal glucose tolerance during pregnancy: systematic review and meta-analysis.Environmental science and pollution research international · 2021Pooled it
- Developmental low-dose bisphenol A exposure leads to extensive transcriptome female masculinization and male feminization later in life.Communications medicine · 2025Article
- Environmental Phenols and Growth in Infancy: The Infant Feeding and Early Development Study.The Journal of clinical endocrinology and metabolism · 2024Article
- Urinary biomarkers of environmental exposures and asthma morbidity in a school inner city asthma study.International journal of hygiene and environmental health · 2024Article
- Parabens effects on female reproductive health - Review of evidence from epidemiological and rodent-based studies.Reproductive toxicology (Elmsford, N.Y.) · 2024Review
- Monitoring human exposure to four parabens and triclosan: comparing silicone wristbands with spot urine samples as predictors of internal dose.Journal of exposure science & environmental epidemiology · 2024Article
- Environmental phenol exposures in 6- to 12-week-old infants: The Infant Feeding and Early Development (IFED) study.Environmental research · 2024Article
- Health Risk Assessment of Occupational Exposures of Polycyclic Aromatic Hydrocarbons, Phthalates, and Semi-Volatile Chlorinated Organic Compounds in Urine of Commercial Fish Smokers, Ghana.Environmental health insights · 2024Article
- Urinary Paraben Concentrations and Associations with the Periconceptional Urinary Metabolome: Untargeted and Targeted Metabolomics Analyses of Participants from the Early Pregnancy Study.Environmental health perspectives · 2023Article
- Urinary phenol concentrations and fecundability and early pregnancy loss.Human reproduction (Oxford, England) · 2023Article
- Exposure to Antibacterial Chemicals Is Associated With Altered Composition of Oral Microbiome.Frontiers in microbiology · 2022Article
- Variability of Urinary Concentrations of Phenols, Parabens, and Triclocarban during Pregnancy in First Morning Voids and Pooled Samples.Environmental science & technology · 2021Article
- Direct LC-MS/MS and indirect GC-MS/MS methods for measuring urinary bisphenol A concentrations are comparable.Environment international · 2021Article
- Exposure to environmental phenols and parabens, and relation to body mass index, eczema and respiratory outcomes in the Norwegian RHINESSA study.Environmental health : a global access science source · 2021Article
- Combined effects of di (2-ethylhexyl) phthalate and bisphenol A on thyroid hormone homeostasis in adolescent female rats.Environmental science and pollution research international · 2020Article
- A framework for assessing the impact of chemical exposures on neurodevelopment in ECHO: Opportunities and challenges.Environmental research · 2020Review
- Opportunities for evaluating chemical exposures and child health in the United States: the Environmental influences on Child Health Outcomes (ECHO) Program.Journal of exposure science & environmental epidemiology · 2020Review
- The Impact of Early-Life Exposure to Antimicrobials on Asthma and Eczema Risk in Children.Current environmental health reports · 2019Review
- Bisphenol a: A narrative review of prenatal exposure effects on adipogenesis and childhood obesity via peroxisome proliferator-activated receptor gamma.Environmental research · 2019Review
- Biomonitoring and Nonpersistent Chemicals-Understanding and Addressing Variability and Exposure Misclassification.Current environmental health reports · 2019Review
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
backgroundExposures to environmental phenols and parabens may be harmful, especially in utero. Prior studies have demonstrated high within-person variability of urinary concentrations across pregnancy.
objectivesWe sought to measure phenol and paraben biomarker concentrations for the Norwegian Mother and Child Cohort (MoBa) study, assess within-person variability, and investigate any possible external phenol or paraben contamination of specimens.
methodsWe collected three spot urine samples at approximately 17, 23, and 29 weeks gestation in a hospital setting and added a preservative containing ethyl paraben. We measured urinary concentrations and within-person variability for phenols and parabens in a MoBa sample (n = 45), including a subgroup of 15 participants previously randomly selected for a bisphenol A (BPA) exposure study who had unusually high total BPA concentrations. Additionally, we compared reliability results for total, conjugated, and free concentrations of phenolic compounds.
resultsWe detected total and free BPA, butyl paraben, propyl paraben, and methyl paraben in 100% of samples, total benzophenone-3 in 95% of samples, and infrequently detected free benzophenone-3 and total and free 2,4-dichlorophenol and 2,5-dichlorophenol. Intraclass correlation coefficients (ICCs) for total, conjugated, and free concentrations ranged from relatively low for BPA to moderate for propyl paraben. ICCs were generally similar overall and by subgroup.
conclusionsUsing conjugated concentrations improved reliability estimates only for BPA. Measuring total and free concentrations, an approach that may be useful for future studies, allowed us to identify likely BPA and butyl paraben contamination of archived MoBa urine specimens.
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