ArticlePloS one2015
Head-to-head comparison of two popular cortical thickness extraction algorithms: a cross-sectional and longitudinal study.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07731191 (Development of Digital Solutions for the Prediction of the Biological Mechanisms of Alzheimer's Disease Through the Analysis of Risk Factors), which is not on this map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Development of Digital Solutions for the Prediction of the Biological Mechanisms of Alzheimer's Disease Through the Analysis of Risk Factors (PrevAI)
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- Structural magnetic resonance imaging for the early diagnosis of dementia due to Alzheimer's disease in people with mild cognitive impairment.The Cochrane database of systematic reviews · 2020Pooled it
- Robust cortical thickness estimation in the presence of partial volumes using adaptive diffusion equation.Journal of neuroscience methods · 2025Article
- Advantages of Using Both Voxel- and Surface-based Morphometry in Cortical Morphology Analysis: A Review of Various Applications.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2022Review
- Integration of Imaging Genomics Data for the Study of Alzheimer's Disease Using Joint-Connectivity-Based Sparse Nonnegative Matrix Factorization.Journal of molecular neuroscience : MN · 2022Article
- Quantitative MRI Harmonization to Maximize Clinical Impact: The RIN-Neuroimaging Network.Frontiers in neurology · 2022Article
- Decreased Cortical Thickness and Local Gyrification in Individuals with Subjective Cognitive Impairment.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2021Article
- Classification of multiple sclerosis based on patterns of CNS regional atrophy covariance.Human brain mapping · 2021Article
- A Simulation Toolkit for Testing the Sensitivity and Accuracy of Corticometry Pipelines.Frontiers in neuroinformatics · 2021Article
- Norms for Automatic Estimation of Hippocampal Atrophy and a Step Forward for Applicability to the Italian Population.Frontiers in neuroscience · 2021Article
- Management and Quality Control of Large Neuroimaging Datasets: Developments From the Barcelonaβeta Brain Research Center.Frontiers in neuroscience · 2021Article
- Medical Informatics Platform (MIP): A Pilot Study Across Clinical Italian Cohorts.Frontiers in neurology · 2020Article
- Cortical Thickness Estimation in Individuals With Cerebral Small Vessel Disease, Focal Atrophy, and Chronic Stroke Lesions.Frontiers in neuroscience · 2020Article
- Normative cerebral cortical thickness for human visual areas.NeuroImage · 2019Article
- Hippocampal atrophy has limited usefulness as a diagnostic biomarker on the early onset Alzheimer's disease patients: A comparison between visual and quantitative assessment.NeuroImage. Clinical · 2019Article
- Multi-study validation of data-driven disease progression models to characterize evolution of biomarkers in Alzheimer's disease.NeuroImage. Clinical · 2019Article
- Brain properties predict proximity to symptom onset in sporadic Alzheimer's disease.Brain : a journal of neurology · 2018Article
- Kernel Methods for Riemannian Analysis of Robust Descriptors of the Cerebral Cortex.Information processing in medical imaging : proceedings of the ... conference · 2017Article
- Advances in Studying Brain Morphology: The Benefits of Open-Access Data.Frontiers in human neuroscience · 2017Article
- Riemannian Statistical Analysis of Cortical Geometry with Robustness to Partial Homology and Misalignment.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention · 2016Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
background and purposeThe measurement of cortical shrinkage is a candidate marker of disease progression in Alzheimer's. This study evaluated the performance of two pipelines: Civet-CLASP (v1.1.9) and Freesurfer (v5.3.0).
methodsImages from 185 ADNI1 cases (69 elderly controls (CTR), 37 stable MCI (sMCI), 27 progressive MCI (pMCI), and 52 Alzheimer (AD) patients) scanned at baseline, month 12, and month 24 were processed using the two pipelines and two interconnected e-infrastructures: neuGRID (https://neugrid4you.eu) and VIP (http://vip.creatis.insa-lyon.fr). The vertex-by-vertex cross-algorithm comparison was made possible applying the 3D gradient vector flow (GVF) and closest point search (CPS) techniques.
resultsThe cortical thickness measured with Freesurfer was systematically lower by one third if compared to Civet's. Cross-sectionally, Freesurfer's effect size was significantly different in the posterior division of the temporal fusiform cortex. Both pipelines were weakly or mildly correlated with the Mini Mental State Examination score (MMSE) and the hippocampal volumetry. Civet differed significantly from Freesurfer in large frontal, parietal, temporal and occipital regions (p<0.05). In a discriminant analysis with cortical ROIs having effect size larger than 0.8, both pipelines gave no significant differences in area under the curve (AUC). Longitudinally, effect sizes were not significantly different in any of the 28 ROIs tested. Both pipelines weakly correlated with MMSE decay, showing no significant differences. Freesurfer mildly correlated with hippocampal thinning rate and differed in the supramarginal gyrus, temporal gyrus, and in the lateral occipital cortex compared to Civet (p<0.05). In a discriminant analysis with ROIs having effect size larger than 0.6, both pipelines yielded no significant differences in the AUC.
conclusionsCivet appears slightly more sensitive to the typical AD atrophic pattern at the MCI stage, but both pipelines can accurately characterize the topography of cortical thinning at the dementia stage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.