Evidence map›Paper›PMID 25781950›Full record

Trial reportPloS one2015

Irisin in blood increases transiently after single sessions of intense endurance exercise and heavy strength training.

Håvard Nygaard, Gunnar Slettaløkken, Geir Vegge, Ivana Hollan, Jon Elling Whist, Tor Strand, Bent R Rønnestad, Stian Ellefsen

Registry-linked trialOpen access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05573321 (Effect of Blood Flow Restriction Exercise on Acute Systemic Irisin, Myostatin and Decorin Levels), which is not on this map. Cited by 71 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 4 pooled it
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05573321 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Effect of Blood Flow Restriction Exercise on Acute Systemic Irisin, Myostatin and Decorin Levels

TypeinterventionalSponsorEge UniversityRan2023 to 2023Enrolled22ConditionsMuscle HypotrophyArmsBFR-RE, HL-RE
3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 4 syntheses or guidelines pooled it, 134 citations in OpenAlex.

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11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Håvard NygaardLillehammer University College, Lillehammer, Norway.
Gunnar SlettaløkkenLillehammer University College, Lillehammer, Norway.
Geir VeggeLillehammer University College, Lillehammer, Norway.
Ivana HollanHospital for Rheumatic Diseases, Lillehammer, Norway.
Jon Elling WhistInnlandet Hospital Trust, Lillehammer, Norway.
Tor StrandInnlandet Hospital Trust, Lillehammer, Norway.
Bent R RønnestadLillehammer University College, Lillehammer, Norway.
Stian EllefsenLillehammer University College, Lillehammer, Norway.
Innlandet Hospital Trust · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeIrisin is a recently identified exercise-induced hormone that increases energy expenditure, at least in rodents. The main purpose of this study was to test the hypothesis that Irisin increases acutely in blood after singular sessions of intense endurance exercise (END) and heavy strength training (STR). Secondary, we wanted to explore the relationship between body composition and exercise-induced effects on irisin, and the effect of END and STR on muscular expression of the irisin gene FNDC5.

methodsNine moderately trained healthy subjects performed three test days using a randomized and standardized crossover design: one day with 60 minutes of END, one day with 60 minutes of STR, and one day without exercise (CON). Venous blood was sampled over a period of 24h on the exercise days.

resultsBoth END and STR led to transient increases in irisin concentrations in blood, peaking immediately after END and one hour after STR, before gradually returning to baseline. Irisin responses to STR, but not END, showed a consistently strong negative correlation with proportions of lean body mass. Neither END nor STR affected expression of FNDC5, measured 4h after training sessions, though both protocols led to pronounced increases in PGC-1α expression, which is involved in transcriptional control of FNDC5.

conclusionThe results strongly suggest that single sessions of intense endurance exercise and heavy strength training lead to transient increases in irisin concentrations in blood. This was not accompanied by increased FNDC5 expression, measured 4h post-exercise. The results suggest that irisin responses to resistance exercise are higher in individuals with lower proportions of lean body mass.

Indexed as

AdultExerciseFemaleFibronectinsHumansMalePeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPhysical EnduranceTranscription FactorsFibronectinsFNDC5 protein, humanPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPPARGC1A protein, humanTranscription Factors

Identifiers

PMID25781950
PMCPMC4363689
OpenAlexW2081741858

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.