ArticlePloS one2015
Tinnitus: a large VBM-EEG correlational study.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Invariant structural and functional brain regions associated with tinnitus: A meta-analysis.PloS one · 2022Pooled it
- A methodological assessment of studies that use voxel-based morphometry to study neural changes in tinnitus patients.Hearing research · 2017Pooled it
- Gray matter declines with age and hearing loss, but is partially maintained in tinnitus.Scientific reports · 2020Trial
- Towards affordable biomarkers of frontotemporal dementia: A classification study via network's information sharing.Scientific reports · 2017Trial
- White Matter Alterations Are More Robust Than Gray Matter Differences in Tinnitus and Hearing Loss: An MRI Study of Military Personnel.Journal of the Association for Research in Otolaryngology : JARO · 2026Article
- Tinnitus and tinnitus disorder: Genetic, neurobiological, and clinical differentiation.iScience · 2026Review
- A scoping review of tinnitus research undertaken by New Zealand researchers: Aotearoa-an international hotspot for tinnitus innovation and collaboration.Journal of the Royal Society of New Zealand · 2025Review
- Hyperacusis in Tinnitus Individuals Is Associated with Smaller Gray Matter Volumes in the Supplementary Motor Area Regardless of Hearing Levels.Brain sciences · 2024Article
- Review and Perspective on Brain Bases of Tinnitus.Journal of the Association for Research in Otolaryngology : JARO · 2023Review
- An Inverse Relationship Between Gray Matter Volume and Speech-in-Noise Performance in Tinnitus Patients with Normal Hearing Sensitivity.Journal of the Association for Research in Otolaryngology : JARO · 2023Article
- Surface-based functional metrics and auditory cortex characteristics in chronic tinnitus.Heliyon · 2022Article
- A Combined Image- and Coordinate-Based Meta-Analysis of Whole-Brain Voxel-Based Morphometry Studies Investigating Subjective Tinnitus.Brain sciences · 2022Article
- Hearing loss is associated with gray matter differences in older adults at risk for and with Alzheimer's disease.Aging brain · 2021Article
- Neurofilament Light Chain Is a Promising Biomarker in Alcohol Dependence.Frontiers in psychiatry · 2021Article
- The Influence of Aging, Hearing, and Tinnitus on the Morphology of Cortical Gray Matter, Amygdala, and Hippocampus.Frontiers in aging neuroscience · 2020Article
- Single-Session of Combined tDCS-TMS May Increase Therapeutic Effects in Subjects With Tinnitus.Frontiers in neurology · 2020Article
- Morphological Neuroimaging Biomarkers for Tinnitus: Evidence Obtained by Applying Machine Learning.Neural plasticity · 2019Article
- Neuroanatomical Alterations in Patients with Early Stage of Unilateral Pulsatile Tinnitus: A Voxel-Based Morphometry Study.Neural plasticity · 2018Article
- Altered Contralateral Auditory Cortical Morphology in Unilateral Sudden Sensorineural Hearing Loss.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2015Article
- Frontostriatal Gating of Tinnitus and Chronic Pain.Trends in cognitive sciences · 2015Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A surprising fact in voxel-based morphometry (VBM) studies performed in tinnitus is that not one single region is replicated in studies of different centers. The question then rises whether this is related to the low sample size of these studies, the selection of non-representative patient subgroups, or the absence of stratification according to clinical characteristics. Another possibility is that VBM is not a good tool to study functional pathologies such as tinnitus, in contrast to pathologies like Alzheimer's disease where it is known the pathology is related to cell loss. In a large sample of 154 tinnitus patients VBM and QEEG (Quantitative Electroencephalography) was performed and evaluated by a regression analysis. Correlation analyses are performed between VBM and QEEG data. Uncorrected data demonstrated structural differences in grey matter in hippocampal and cerebellar areas related to tinnitus related distress and tinnitus duration. After control for multiple comparisons, only cerebellar VBM changes remain significantly altered. Electrophysiological differences are related to distress, tinnitus intensity, and tinnitus duration in the subgenual anterior cingulate cortex, dorsal anterior cingulate cortex, hippocampus, and parahippocampus, which confirms previous results. The absence of QEEG-VBM correlations suggest functional changes are not reflected by co-occurring structural changes in tinnitus, and the absence of VBM changes (except for the cerebellum) that survive correct statistical analysis in a large study population suggests that VBM might not be very sensitive for studying tinnitus.
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Registered trials
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