ArticlePloS one2015
A single pair of neurons modulates egg-laying decisions in Drosophila.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 28 citations in OpenAlex.
- A distinct neural ensemble to integrate contradictory information and form long-term memory inScience advances · 2025Article
- Forgotten memory storage and retrieval in Drosophila.Nature communications · 2023Article
- Regulation and modulation of biogenic amine neurotransmission inFrontiers in physiology · 2023Review
- An internal expectation guidesScience advances · 2022Article
- Serotonin Signals Modulate Mushroom Body Output Neurons for Sustaining Water-Reward Long-Term Memory inFrontiers in cell and developmental biology · 2021Article
- Mushroom body subsets encode CREB2-dependent water-reward long-term memory in Drosophila.PLoS genetics · 2020Article
- MDN brain descending neurons coordinately activate backward and inhibit forward locomotion.eLife · 2018Article
- Ingestion of artificial sweeteners leads to caloric frustration memory in Drosophila.Nature communications · 2017Article
- Neural circuits for long-term water-reward memory processing in thirsty Drosophila.Nature communications · 2017Article
- Drosophila Neprilysins Are Involved in Middle-Term and Long-Term Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Additive Expression of Consolidated Memory through Drosophila Mushroom Body Subsets.PLoS genetics · 2016Article
- High Throughput Assay to Examine Egg-Laying Preferences of Individual Drosophila melanogaster.Journal of visualized experiments : JoVE · 2016Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Animals have to judge environmental cues and choose the most suitable option for them from many different options. Female fruit flies selecting an optimum site to deposit their eggs is a biologically important reproductive behavior. When given the direct choice between ovipositing their eggs in a sucrose-containing medium or a caffeine-containing medium, female flies prefer the latter. However, the neural circuits and molecules that regulate this decision-making processes during egg-laying site selection remain poorly understood. In the present study, we found that amnesiac (amn) mutant flies show significant defects in egg-laying decisions, and such defects can be reversed by expressing the wild-type amn transgene in two dorsal paired medial (DPM) neurons in the brain. Silencing neuronal activity with an inward rectifier potassium channel (Kir2.1) in DPM neurons also impairs egg-laying decisions. Finally, the activity in mushroom body αβ neurons is required for the egg-laying behavior, suggesting a possible "DPM-αβ neurons" brain circuit modulating egg-laying decisions. Our results highlight the brain circuits and molecular mechanisms of egg-laying decisions in Drosophila.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.