Evidence map›Paper›PMID 25781903›Full record

ArticleThe Clinical neuropsychologist2015

Antiretroviral Non-Adherence is Associated With a Retrieval Profile of Deficits in Verbal Episodic Memory.

Lisa C Obermeit, Erin E Morgan, Kaitlin B Casaletto, Igor Grant, Steven Paul Woods, HIV Neurobehavioral Research Program Group

Abstract read
In one paragraph

Article in The Clinical neuropsychologist, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
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  6. Article
  7. Verbal Learning Mediates the Relationship Between Executive Functions and a Laboratory Task of Medication Management in HIV Disease.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2021
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  8. Article
  9. Review
  10. Article
  11. Article
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  14. Sex differences in HIV effects on visual memory among substance-dependent individuals.Journal of clinical and experimental neuropsychology · 2017
    Article
  15. Article
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lisa C Obermeita The HIV Neurobehavioral Research Program , University of California , San Diego , CA 92103-8231 , USA.
Erin E Morgan
Kaitlin B Casaletto
Igor Grant
Steven Paul Woods
HIV Neurobehavioral Research Program Group

Funding

STRUCTURAL NEUROIMAGING COREP30MH062512 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jennifer E Iudicello · 2001 to 2026
$50.4M
Prospective Memory in HIV-1 InfectionR01MH073419 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WOODS, STEVEN PAUL · 2005 to 2017
$6.6M
Training in Research on Addictions in Interdisciplinary NeuroAIDS (TRAIN)T32DA031098 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jennifer E Iudicello, DAVID J MOORE · 2011 to 2026
$4.6M
A Metacognition-based Approach to Improve HAND Among Methamphetamine UsersF31DA035708 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CASALETTO, KAITLIN B · 2013 to 2015
$99k
NIDA NIH HHS F31 DA035708NIDA NIH HHS F31-DA035708NIDA NIH HHS L30 DA032120NIDA NIH HHS L30-DA032120NIDA NIH HHS T32 DA031098NIDA NIH HHS T32-DA31098NIMH NIH HHS P30 MH062512NIMH NIH HHS P30-MH62512NIMH NIH HHS R01 MH073419NIMH NIH HHS R01-MH073419
6 · The paper itself

Abstract

HIV-associated deficits in verbal episodic memory are commonly associated with antiretroviral non-adherence; however, the specific aspects of memory functioning (e.g., encoding, consolidation, or retrieval) that underlie this established relationship are not well understood. This study evaluated verbal memory profiles of 202 HIV+ participants who underwent a 30-day electronic monitoring of antiretroviral adherence. At the group level, non-adherence was significantly associated with lower scores on immediate and delayed passage recall and word list learning. Retention and recognition of passages and word lists were not related to adherence. Participants were then classified as having either a normal verbal memory profile, a "subcortical" retrieval profile (i.e., impaired free recall with relatively spared recognition), or a "cortical" encoding profile (e.g., cued recall intrusions) based on the Massman et al. ( 1990 ) algorithm for the California Verbal Learning Test. HIV+ participants with a classic retrieval deficit had significantly greater odds of being non-adherent than participants with a normal or encoding profile. These findings suggest that adherence to prescribed antiretroviral regimens may be particularly vulnerable to disruption in HIV+ individuals due to deficits in the complex process of efficiently accessing verbal episodic information with minimal cues. A stronger relationship between non-adherence and passage (vs. word list) recall was also found and may reflect the importance of contextual features in remembering to take medications. Targeted interventions for enhancing and supporting episodic memory retrieval processes may improve antiretroviral adherence and overall health outcomes among persons living with HIV.

Indexed as

Executive FunctionMemory, EpisodicMental RecallVerbal LearningAdultAnti-Retroviral AgentsFemaleHumansMaleMedication AdherenceMemory DisordersMiddle AgedNeuropsychological TestsAnti-Retroviral AgentsImmediate recallLong-term memoryMedication compliance.RecognitionWechsler scales

Identifiers

PMID25781903
PMCPMC4425586

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.