ArticlePloS one2015
Polymorphisms of chicken TLR3 and 7 in different breeds.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 19 citations in OpenAlex.
- The Potential of Toll-Like Receptors to Modulate Avian Immune System: Exploring the Effects of Genetic Variants and Phytonutrients.Frontiers in genetics · 2021Review
- RIGI, TLR7, and TLR3 Genes Were Predicted to Have Immune Response Against Avian Influenza in Indigenous Ducks.Frontiers in molecular biosciences · 2021Article
- Infectious bronchitis virus inhibits activation of the TLR7 pathway, but not the TLR3 pathway.Archives of virology · 2020Article
- Isolation of peripheral blood mononuclear cells and the expression of toll-like receptors in Betong chickens.Veterinary world · 2020Article
- Avian Pattern Recognition Receptor Sensing and Signaling.Veterinary sciences · 2020Review
- Avian Toll-like receptor allelic diversity far exceeds human polymorphism: an insight from domestic chicken breeds.Scientific reports · 2018Article
- Polymorphisms in pattern recognition receptor genes of indigenous and White Leghorn breeds of chicken.Archives animal breeding · 2018Article
- Transcriptome analysis of avian reovirus-mediated changes in gene expression of normal chicken fibroblast DF-1 cells.BMC genomics · 2017Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Toll-like receptors (TLRs) mediate immune responses via the recognition of pathogen-associated molecular patterns (PAMPs), thus playing important roles in host defense. Among the chicken (Ch) TLR family, ChTLR3 and 7 have been shown to recognize viral RNA. In our earlier studies, we have reported polymorphisms of TLR1, 2, 4, 5, 15 and 21. In the present study, we amplified TLR3 and 7 genes from different chicken breeds and analyzed their sequences. We identified 7 amino acid polymorphism sites in ChTLR3 with 6 outer part sites and 1 inner part site, and 4 amino acid polymorphism sites in ChTLR7 with 3 outer part sites and 1 inner part site. These results demonstrate that ChTLR genes are polymorphic among different chicken breeds, suggesting a varied resistance across numerous chicken breeds. This information might help improve chicken health by breeding and vaccination.
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