ArticlePloS one2015
Risk of cancer in patients with iron deficiency anemia: a nationwide population-based study.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 40 papers, 1 of them a synthesis that pooled it.
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 80 citations in OpenAlex.
- Iron intake, body iron status, and risk of breast cancer: a systematic review and meta-analysis.BMC cancer · 2019Pooled it
- Iron status from diet and serum in relation to biological aging acceleration: A NHANES cross-sectional study.Asia Pacific journal of clinical nutrition · 2026Article
- Iron Status, Erythropoietin, and Cancer Incidence in the General Population.European journal of clinical investigation · 2026Article
- Gastric MALT Lymphoma in Plummer-Vinson Syndrome: Broadening the Spectrum of Associated Malignancies.ACG case reports journal · 2026Article
- Systemic iron availability differentially shapes tumor and brain iron handling in a sex-dependent manner in glioblastoma.PloS one · 2026Article
- Article
- Anaemia, ethnicity, and cancer incidence: a retrospective cohort study in primary care.The British journal of general practice : the journal of the Royal College of General Practitioners · 2025Article
- Diagnostic work-up of anemia and associated health outcomes in people with heart failure.BMC medicine · 2025Observational
- Inflammatory diseases and risk of lung cancer among individuals who have never smoked.Nature communications · 2025Article
- Causal associations between iron deficiency anemia and digestive system cancers: evidence from a bidirectional two-sample Mendelian randomization study.Discover oncology · 2025Article
- Iron deficiency anemia-related mortality trends in US older subjects, 1999 to 2019.Aging clinical and experimental research · 2025Article
- Exploring modifiable risk factors: insights from Mendelian randomization analyses of gastric cancer in East Asian populations.Discover oncology · 2025Article
- Iron and Cancer.Advances in experimental medicine and biology · 2025Review
- Iron and cancer: overview of the evidence from population-based studies.Frontiers in oncology · 2024Review
- Determinants of anemia among patients receiving cancer chemotherapy in Northwest Ethiopia.Frontiers in medicine · 2024Article
- Iron metabolism in colorectal cancer: a balancing act.Cellular oncology (Dordrecht, Netherlands) · 2023Review
- Impact of low serum iron on treatment outcome of PD-1 inhibitors in advanced gastric cancer.BMC cancer · 2023Article
- Malignancy-related mir-210, mir-373 and let-7 levels are affected in iron deficiency anemia.African health sciences · 2023Article
- Article
- Clinically Deployable Bioelectronic Sensing Platform for Ultrasensitive Detection of Transferrin in Serum Sample.Biosensors · 2023Article
Corrections and comments
- Erratum issued
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study evaluated the risk of cancer among patients with iron deficiency anemia (IDA) by using a nationwide population-based data set.
methodPatients newly diagnosed with IDA and without antecedent cancer between 2000 and 2010 were recruited from the Taiwan National Health Insurance Research Database. The standardized incidence ratios (SIRs) of cancer types among patients with IDA were calculated.
resultsPatients with IDA exhibited an increased overall cancer risk (SIR: 2.15). Subgroup analysis showed that patients of both sexes and in all age groups had an increased SIR. After we excluded patients diagnosed with cancer within the first and first 5 years of IDA diagnosis, the SIRs remained significantly elevated at 1.43 and 1.30, respectively. In addition, the risks of pancreatic (SIR: 2.31), kidney (SIR: 2.23), liver (SIR: 1.94), and bladder cancers (SIR: 1.74) remained significantly increased after exclusion of patients diagnosed with cancer within 5 years after IDA diagnosis.
conclusionThe overall cancer risk was significantly elevated among patients with IDA. After we excluded patients diagnosed with IDA and cancer within 1 and 5 years, the SIRs remained significantly elevated compared with those of the general population. The increased risk of cancer was not confined to gastrointestinal cancer when the SIRs of pancreatic, kidney, liver, and bladder cancers significantly increased after exclusion of patients diagnosed with IDA and cancer within the first 5 years. This finding may be caused by immune activities altered by IDA. Further study is necessary to determine the association between IDA and cancer risk.
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