ArticleTranslational psychiatry2015
Developmental white matter microstructure in autism phenotype and corresponding endophenotype during adolescence.
Article in Translational psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Brain structural correlates of autistic traits across the diagnostic divide: A grey matter and white matter microstructure study.NeuroImage. Clinical · 2021Article
- Brain connectivity analysis in fathers of children with autism.Cognitive neurodynamics · 2020Article
- Face individual identity recognition: a potential endophenotype in autism.Molecular autism · 2020Article
- Age-related differences in white matter diffusion measures in autism spectrum condition.Molecular autism · 2020Article
- Adolescent-Specific Motivation Deficits in Autism Versus Typical Development.Journal of autism and developmental disorders · 2020Article
- Developmental changes of cortical white-gray contrast as predictors of autism diagnosis and severity.Translational psychiatry · 2018Article
- White matter endophenotypes and correlates for the clinical diagnosis of autism spectrum disorder.Social cognitive and affective neuroscience · 2018Article
- Atypical age-dependency of executive function and white matter microstructure in children and adolescents with autism spectrum disorders.European child & adolescent psychiatry · 2017Article
- Age-related differences in autism: The case of white matter microstructure.Human brain mapping · 2017Article
- Default Mode Hypoconnectivity Underlies a Sex-Related Autism Spectrum.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2016Article
- Frontal networks in adults with autism spectrum disorder.Brain : a journal of neurology · 2016Article
- Risk Factors Associated With Language in Autism Spectrum Disorder: Clues to Underlying Mechanisms.Journal of speech, language, and hearing research : JSLHR · 2016Review
- Whole-brain functional hypoconnectivity as an endophenotype of autism in adolescents.NeuroImage. Clinical · 2015Article
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
During adolescence, white matter microstructure undergoes an important stage of development. It is hypothesized that the alterations of brain connectivity that have a key role in autism spectrum conditions (ASCs) may interact with the development of white matter microstructure. This interaction may be present beyond the phenotype of autism in siblings of individuals with ASC, who are 10 to 20 times more likely to develop certain forms of ASC. We use diffusion tensor imaging to examine how white matter microstructure measurements correlate with age in typically developing individuals, and how this correlation differs in n=43 adolescents with ASC and their n=38 siblings. Correlations observed in n=40 typically developing individuals match developmental changes noted in previous longitudinal studies. In comparison, individuals with ASC display weaker negative correlation between age and mean diffusivity in a broad area centred in the right superior longitudinal fasciculus. These differences may be caused either by increased heterogeneity in ASC or by temporal alterations in the group's developmental pattern. Siblings of individuals with ASC also show diminished negative correlation between age and one component of mean diffusivity-second diffusion eigenvalue-in the right superior longitudinal fasciculus. As the observed differences match for location and correlation directionality in our comparison of typically developing individuals to those with ASC and their siblings, we propose that these alterations constitute a part of the endophenotype of autism.
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Registered trials
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