ArticleNutrients2015
Folate deficiency decreases apoptosis of endometrium decidual cells in pregnant mice via the mitochondrial pathway.
Article in Nutrients, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Mitochondrial dysfunction in pregnancy loss: a review.Molecular and cellular biochemistry · 2025Review
- RNA Sequencing Reveals the Involvement of Serum Exosomal miRNAs in Early Pregnancy in Cattle.Animals : an open access journal from MDPI · 2024Article
- The regulated cell death at the maternal-fetal interface: beneficial or detrimental?Cell death discovery · 2024Review
- Recent Advances in Folates and Autoantibodies against Folate Receptors in Early Pregnancy and Miscarriage.Nutrients · 2023Review
- JAZF1 safeguards human endometrial stromal cells survival and decidualization by repressing the transcription of G0S2.Communications biology · 2023Article
- Probiotic Potential of a Folate-Producing StrainFoods (Basel, Switzerland) · 2022Article
- Decidualization and Related Pregnancy Complications.Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2022Review
- miRNA profiling in intrauterine exosomes of pregnant cattle on day 7.Frontiers in veterinary science · 2022Article
- Perfluorooctanoic acid exposure in early pregnancy induces oxidative stress in mice uterus and liver.Environmental science and pollution research international · 2021Article
- Proteomic analysis of decidua in patients with recurrent pregnancy loss (RPL) reveals mitochondrial oxidative stress dysfunction.Clinical proteomics · 2021Article
- Endometrial autophagy is essential for embryo implantation during early pregnancy.Journal of molecular medicine (Berlin, Germany) · 2020Article
- Decreased autophagy was implicated in the decreased apoptosis during decidualization in early pregnant mice.Journal of molecular histology · 2018Article
- Expression of mmu-miR-96 in the endometrium during early pregnancy and its regulatory effects on stromal cell apoptosis via Bcl2.Molecular medicine reports · 2017Article
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Authors and funding
10 authors.
Funding
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Abstract
It is well known that maternal folate deficiency results in adverse pregnancy outcomes. In addition to aspects in embryonic development, maternal uterine receptivity and the decidualization of stromal cells is also very important for a successful pregnancy. In this study, we focused on endometrium decidualization and investigated whether apoptosis, which is essential for decidualization, was impaired. Flow cytometry and TUNEL detection revealed that apoptosis of mouse endometrium decidual cells was suppressed in the dietary folate-deficient group on Days 7 and 8 of pregnancy (Day 1 = vaginal plug) when decidua regression is initiated. The endometrium decidual tissue of the folate deficiency group expressed less Bax compared to the normal diet group while they had nearly equal expression of Bcl2 protein. Further examination revealed that the mitochondrial transmembrane potential (ΔΨm) decreased, and the fluorescence of diffuse cytoplasmic cytochrome c protein was detected using laser confocal microscopy in normal decidual cells. However, no corresponding changes were observed in the folate-deficient group. Western blotting analyses confirmed that more cytochrome c was released from mitochondria in normal decidual cells. Taken together, these results demonstrated that folate deficiency could inhibit apoptosis of decidual cells via the mitochondrial apoptosis pathway, thereby restraining decidualization of the endometrium and further impairing pregnancy.
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