ReviewMolecules (Basel, Switzerland)2015
Potential role of olive oil phenolic compounds in the prevention of neurodegenerative diseases.
Review in Molecules (Basel, Switzerland), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
86 citing papers in PubMed, 1 synthesis or guideline pooled it, 225 citations in OpenAlex.
- The effects of olive oil consumption on cognitive performance: a systematic review.Frontiers in nutrition · 2023Pooled it
- Effect of olive oil phenolic compounds on the expression of blood pressure-related genes in healthy individuals.European journal of nutrition · 2017Trial
- Momast Protects SH-SY5Y Cells Against Heavy Metal-Induced Neurotoxicity Through Complementary Membrane-Dependent and Intracellular Mechanisms.International journal of molecular sciences · 2026Article
- An Integrated Screening Study of Polyphenol Recovery from Olive Mill Wastewater Using Cationic Starch-Assisted Clarification and Adsorption Resin Purification.Antioxidants (Basel, Switzerland) · 2026Article
- A Healthy Lifestyle Can Slow Immune System Aging and Reduce Age-Related Chronic Inflammation: A Narrative Review.International journal of molecular sciences · 2026Review
- Extra-Virgin Olive Oil Phenolics in IBD-Associated Vascular Risk.Molecules (Basel, Switzerland) · 2026Review
- Mediterranean Diet, Polyphenols, and Neuroprotection: Mechanistic Insights into Resveratrol and Oleuropein.Nutrients · 2025Review
- Effects of Adding Hydroxytyrosol to the Diet of Pigs in the Nursery Phase on Growth Performance, Biochemical Markers, and Fatty Acid Profile.Animals : an open access journal from MDPI · 2025Article
- Spontaneous Reaction of Oleacein and Oleocanthal with Primary Amines: A Biochemical Perspective.Molecules (Basel, Switzerland) · 2025Article
- Impact of pharmacokinetic enhancement strategies on the antimicrobial and antioxidant activities of hydroxytyrosol.RSC advances · 2025Article
- Hydroxytyrosol: biological activities and potential application in livestock production.Frontiers in veterinary science · 2025Review
- Exploring associations between nutritional intake and cognitive performance in Spanish older adults.Frontiers in nutrition · 2025Article
- Hydroxytyrosol protects isoproterenol-induced myocardial infarction through activating notch signaling.Iranian journal of basic medical sciences · 2025Article
- The Role of Greek Olive Leaf Extract in Patients with Mild Alzheimer's Disease (the GOLDEN Study): A Randomized Controlled Clinical Trial.Neurology international · 2024Article
- Review
- Characterization of Olive Oil Phenolic Extracts and Their Effects on the Aggregation of the Alzheimer's Amyloid-β Peptide and Tau.ACS omega · 2024Article
- Neuroprotective Effects of Olive Oil: A Comprehensive Review of Antioxidant Properties.Antioxidants (Basel, Switzerland) · 2024Review
- Cardioprotective effect of oleuropein in a cisplatin-induced cardiotoxicity model in rats.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- Extra-Virgin Olive Oil in Alzheimer's Disease: A Comprehensive Review of Cellular, Animal, and Clinical Studies.International journal of molecular sciences · 2024Review
- Redox Homeostasis and Nrf2-Regulated Mechanisms Are Relevant to Male Infertility.Antioxidants (Basel, Switzerland) · 2024Review
26 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adherence to the Mediterranean Diet (MD) has been associated with a reduced incidence of neurodegenerative diseases and better cognitive performance. Virgin olive oil, the main source of lipids in the MD, is rich in minor phenolic components, particularly hydroxytyrosol (HT). HT potent antioxidant and anti-inflammatory actions have attracted researchers' attention and may contribute to neuroprotective effects credited to MD. In this review HT bioavailability and pharmacokinetics are presented prior to discussing health beneficial effects. In vitro and in vivo neuroprotective effects together with its multiple mechanisms of action are reviewed. Other microconstituents of olive oil are also considered due to their potential neuroprotective effects (oleocanthal, triterpenic acids). Finally, we discuss the potential role of HT as a therapeutic tool in the prevention of neurodegenerative diseases.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.