ArticlePloS one2015
Analysis of resistance to antimicrobials and presence of virulence/stress response genes in Campylobacter isolates from patients with severe diarrhoea.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Rodent-Related Zoonotic Pathogens at the Human-Animal-Environment Interface in Qatar: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2021Pooled it
- Characterization of thermophilicIranian journal of veterinary research · 2026Article
- Campylobacteriosis: A rising threat in foodborne illnesses.Open veterinary journal · 2024Review
- Genomic and clinical characteristics of campylobacteriosis in Australia.Microbial genomics · 2024Article
- A scoping review of factors associated with antimicrobial-resistantEpidemiology and infection · 2023Article
- Rodent-borne zoonoses in Qatar: A possible One-Health framework for the intervention of future epidemic.One health (Amsterdam, Netherlands) · 2023Review
- Evolution and Role of Proteases inBiomolecules · 2023Review
- Identification of genes associated with environmental persistence in Campylobacter jejuni and Campylobacter coli isolates from processing in a broiler abattoir.Veterinary research communications · 2022Article
- Prevalence, antimicrobial resistance, virulence gene profile and molecular typing of Campylobacter species isolated from poultry meat samples.Veterinary medicine and science · 2022Article
- Diversity of bacterial pathogens and their antimicrobial resistance profile among commensal rodents in Qatar.Veterinary research communications · 2022Article
- Article
- Article
- Review
- Morphometric Study ofAnimals : an open access journal from MDPI · 2021Article
- First Report ofAnimals : an open access journal from MDPI · 2020Article
- Prevalence, molecular detection, and virulence gene profiles ofVeterinary world · 2020Article
- Mixed Aetiology of Diarrhoea in Infants Attending Clinics in the North-West Province of South Africa: Potential for Sub-Optimal Treatment.Pathogens (Basel, Switzerland) · 2020Article
- Identification of Campylobacter fetus subsp. venerealis virulence genes in cervical mucus from cows.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2019Article
- Campylobacter at the Human-Food Interface: The African Perspective.Pathogens (Basel, Switzerland) · 2019Review
- Characterization and Phylogenetic Analysis ofInternational journal of environmental research and public health · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Campylobacter infections are a major cause of diarrhoea world-wide and two of the antimicrobials used for their control (erythromycin and ciprofloxacin) have been losing efficacy in recent years. In a sample of 174 genotyped isolates from the stools of patients with severe diarrhoea in Qatar, collected between 2005 and 2012, 63.2% showed resistance to ciprofloxacin, 8.6% to erythromycin, 0.57% to chloramphenicol and all were sensitive to gentamycin. While 33.9% of isolates were sensitive to all four antimicrobials, 59.8% were resistant to at least one, 6.3% were resistant to two and none showed resistance to three antimicrobials. There was no host sex- or age-dependence among isolates resistant to ciprofloxacin and erythromycin and no significant variation was found with the region of origin of the patients. All isolates were screened for the presence of 3 virulence factors (ciaB, cadF and cdtB) and two stress-response factors (htrB and clpP), all of which were present in more than 50% of the isolates. Host sex-, age- and region of origin-dependent variations in prevalence were found for some of these factors. Data analysis for the combination of virulence factors and their effect on antimicrobial resistance indicated that the prevalence of resistance to both erythromycin and ciprofloxacin was higher in isolates harbouring ciaB but not clpP. Prevalence of resistance to ciprofloxacin was similar in clpP positive and negative isolates also possessing htrB, while for htrB-negative isolates prevalence was higher in the absence of clpP. These results are discussed and their implications are highlighted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.