Evidence map›Paper›PMID 25780901›Full record

ReviewProteomics2015

Proteomics analysis of bodily fluids in pancreatic cancer.

Sheng Pan, Teresa A Brentnall, Ru Chen

Abstract readReview
In one paragraph

Review in Proteomics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  17. Analysing the nanoparticle-protein corona for potential molecular target identification.Journal of controlled release : official journal of the Controlled Release Society · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sheng PanDepartment of Medicine, University of Washington, Seattle, WA, USA.
Teresa A BrentnallDepartment of Medicine, University of Washington, Seattle, WA, USA.
Ru ChenDepartment of Medicine, University of Washington, Seattle, WA, USA.

Funding

Early detection of pancreatic cancer in diabeticsR01CA180949 · NCI · UNIVERSITY OF WASHINGTON · PI CHEN, RU, PAN, SHENG · 2014 to 2018
$2.9M
Quantitative glycoproteomics for pancreatic cancer studiesK25CA137222 · NCI · UNIVERSITY OF WASHINGTON · PI PAN, SHENG · 2010 to 2014
$612k
Aberrant Glycosylation Signature in Pancreatic CancerR21CA149772 · NCI · UNIVERSITY OF WASHINGTON · PI BRENTNALL, TERESA A, PAN, SHENG · 2011 to 2012
$396k
Pancreatic Juice Biomarker for Pancreatic CancerR21CA161575 · NCI · UNIVERSITY OF WASHINGTON · PI CHEN, RU · 2011 to 2012
$388k
NCI NIH HHS K25 CA137222NCI NIH HHS K25CA137222NCI NIH HHS R01 CA180949NCI NIH HHS R01CA180949NCI NIH HHS R21 CA149772NCI NIH HHS R21CA149772NCI NIH HHS R21 CA161575NCI NIH HHS R21CA161575
6 · The paper itself

Abstract

Proteomics study of pancreatic cancer using bodily fluids emphasizes biomarker discovery and clinical application, presenting unique prospect and challenges. Depending on the physiological nature of the bodily fluid and its proximity to pancreatic cancer, the proteomes of bodily fluids, such as pancreatic juice, pancreatic cyst fluid, blood, bile, and urine, can be substantially different in terms of protein constitution and the dynamic range of protein concentration. Thus, a comprehensive discovery and specific detection of cancer-associated proteins within these varied fluids is a complex task, requiring rigorous experiment design and a concerted approach. While major challenges still remain, fluid proteomics studies in pancreatic cancer to date have provided a wealth of information in revealing proteome alterations associated with pancreatic cancer in various bodily fluids.

Indexed as

BileBody FluidsCyst FluidHumansMass SpectrometryPancreatic CystPancreatic JuicePancreatic NeoplasmsProteomeProteomicsProteomeBiomedicineBodily fluidsMass spectrometryPancreatic cancerPancreatic ductal adenocarcinomaProteomics

Identifiers

PMID25780901
PMCPMC4526406

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.