ArticlePeerJ2015
Prolonged decay of molecular rate estimates for metazoan mitochondrial DNA.
Article in PeerJ, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Mitochondrial genomes of Psylloidea (Hemiptera): candidate broad-range primers for long-polymerase chain reaction, genewise variability, and calibration-sensitive time-calibrated phylogeny.Journal of insect science (Online) · 2026Article
- The Tien Shan vole (Ecology and evolution · 2021Article
- When parasites persist: tapeworms survive host extinction and reveal waves of dispersal across Beringia.Proceedings. Biological sciences · 2020Article
- Mitochondrial DNAs provide insight into trypanosome phylogeny and molecular evolution.BMC evolutionary biology · 2020Article
- Counterbalancing the time-dependent effect on the human mitochondrial DNA molecular clock.BMC evolutionary biology · 2020Article
- Loss and gain of sexual reproduction in the same stick insect.Molecular ecology · 2019Article
- Bayesian Inference of Evolutionary Histories under Time-Dependent Substitution Rates.Molecular biology and evolution · 2019Article
- Unexpected low genetic variation in the South American hystricognath rodent Lagostomus maximus (Rodentia: Chinchillidae).PloS one · 2019Article
- A comparison of methods for estimating substitution rates from ancient DNA sequence data.BMC evolutionary biology · 2018Article
- Ice age unfrozen: severe effect of the last interglacial, not glacial, climate change on East Asian avifauna.BMC evolutionary biology · 2017Article
- Genome-scale rates of evolutionary change in bacteria.Microbial genomics · 2016Article
- Large-scale mitogenomics enables insights into Schizophora (Diptera) radiation and population diversity.Scientific reports · 2016Article
- Phylogeography of the Chydorus sphaericus Group (Cladocera: Chydoridae) in the Northern Palearctic.PloS one · 2016Article
- Mitogenomic analysis of a 50-generation chicken pedigree reveals a rapid rate of mitochondrial evolution and evidence for paternal mtDNA inheritance.Biology letters · 2015Article
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Authors and funding
2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Evolutionary timescales can be estimated from genetic data using the molecular clock, often calibrated by fossil or geological evidence. However, estimates of molecular rates in mitochondrial DNA appear to scale negatively with the age of the clock calibration. Although such a pattern has been observed in a limited range of data sets, it has not been studied on a large scale in metazoans. In addition, there is uncertainty over the temporal extent of the time-dependent pattern in rate estimates. Here we present a meta-analysis of 239 rate estimates from metazoans, representing a range of timescales and taxonomic groups. We found evidence of time-dependent rates in both coding and non-coding mitochondrial markers, in every group of animals that we studied. The negative relationship between the estimated rate and time persisted across a much wider range of calibration times than previously suggested. This indicates that, over long time frames, purifying selection gives way to mutational saturation as the main driver of time-dependent biases in rate estimates. The results of our study stress the importance of accounting for time-dependent biases in estimating mitochondrial rates regardless of the timescale over which they are inferred.
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