Evidence map›Paper›PMID 25780749›Full record

ArticleBiomedical optics express2015

Quantitative polarized light microscopy of human cochlear sections.

Jacob C M Low, Thomas J Ober, Gareth H McKinley, Konstantina M Stankovic

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical optics express, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Jacob C M LowThe University of Manchester, Oxford Road, Manchester, M13 9PL, UK.
Thomas J OberMassachusetts Institute of Technology, Department of Mechanical Engineering, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.
Gareth H McKinleyMassachusetts Institute of Technology, Department of Mechanical Engineering, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.
Konstantina M StankovicMassachusetts Eye and Ear Infirmary, Department of Otolaryngology and Eaton Peabody Laboratories, 243 Charles Street, Boston, Massachusetts 02114, USA ; Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts, USA.
Massachusetts Institute of Technology · USUniversity of Manchester · GB

Funding

Understanding Noise-Induced Delayed Primary Degeneration of the Auditory NerveK08DC010419 · NIDCD · MASSACHUSETTS EYE AND EAR INFIRMARY · PI STANKOVIC, KONSTANTINA M · 2010 to 2014
$1.2M
NIDCD NIH HHS K08 DC010419
6 · The paper itself

Abstract

Dysfunction of the inner ear is the most common cause of sensorineural hearing loss, which is the most common sensory deficit worldwide. Conventional imaging modalities are unable to depict the microanatomy of the human inner ear, hence the need to explore novel imaging modalities. We provide the first characterization of the polarization dependent optical properties of human cochlear sections using quantitative polarized light microscopy (qPLM). Eight pediatric cadaveric cochlear sections, aged 0 (term) to 24 months, were selected from the US National Temporal Bone Registry, imaged with qPLM and analyzed using Image J. Retardance of the bony otic capsule and basilar membrane were substantially higher than that of the stria vascularis, spiral ganglion neurons, organ of Corti and spiral ligament across the half turns of the spiraling cochlea. qPLM provides quantitative information about the human inner ear, and awaits future exploration in vivo.

Indexed as

(170.3880) Medical and biological imaging(170.4500) Optical coherence tomography(170.4580) Optical diagnostics for medicine(170.4940) Otolaryngology(180.0180) Microscopy

Identifiers

PMID25780749
PMCPMC4354578
OpenAlexW1986169260

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.