ArticleBiomedical optics express2015
In vivo wide-field reflectance/fluorescence imaging and polarization-sensitive optical coherence tomography of human oral cavity with a forward-viewing probe.
Article in Biomedical optics express, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- A Novel Small Form-Factor Handheld Optical Coherence Tomography Probe for Oral Soft Tissue Imaging.Micromachines · 2024Article
- Quantitative Evaluation of Caries and Calculus with Ultrahigh-Resolution Optical Coherence Tomography.Bioengineering (Basel, Switzerland) · 2023Article
- Label-Free Imaging and Histo-Optical Evaluation of Head and Neck Cancers with Multiphoton Autofluorescence Microscopy.Cancers · 2023Article
- Multimodal optical imaging with real-time projection of cancer risk and biopsy guidance maps for early oral cancer diagnosis and treatment.Journal of biomedical optics · 2023Article
- Multimodal widefield fluorescence imaging with nonlinear optical microscopy workflow for noninvasive oral epithelial neoplasia detection: a preclinical study.Journal of biomedical optics · 2020Article
- Influence of tissue fixation on depth-resolved birefringence of oral cavity tissue samples.Journal of biomedical optics · 2020Article
- Low-cost, ultracompact handheld optical coherence tomography probe for in vivo oral maxillofacial tissue imaging.Journal of biomedical optics · 2020Article
- Depth-resolved birefringence imaging of collagen fiber organization in the human oral mucosaBiomedical optics express · 2019Article
- Assessment of the radiofrequency ablation dynamics of esophageal tissue with optical coherence tomography.Journal of biomedical optics · 2017Article
- Human ex-vivo oral tissue imaging using spectral domain polarization sensitive optical coherence tomography.Lasers in medical science · 2017Article
- Automated algorithm for actinic cheilitis diagnosis by wide-field fluorescence imaging.Journal of medical imaging (Bellingham, Wash.) · 2016Article
- Visualization of prostatic nerves by polarization-sensitive optical coherence tomography.Biomedical optics express · 2016Article
- Wide-field in vivo oral OCT imaging.Biomedical optics express · 2015Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report multimodal imaging of human oral cavity in vivo based on simultaneous wide-field reflectance/fluorescence imaging and polarization-sensitive optical coherence tomography (PS-OCT) with a forward-viewing imaging probe. Wide-field reflectance/fluorescence imaging and PS-OCT were to provide both morphological and fluorescence information on the surface, and structural and birefringent information below the surface respectively. The forward-viewing probe was designed to access the oral cavity through the mouth with dimensions of approximately 10 mm in diameter and 180 mm in length. The probe had field of view (FOV) of approximately 5.5 mm in diameter, and adjustable depth of field (DOF) from 2 mm to 10 mm by controlling numerical aperture (NA) in the detection path. This adjustable DOF was to accommodate both requirements for image-based guiding with high DOF and high-resolution, high-sensitivity imaging with low DOF. This multimodal imaging system was characterized by using a tissue phantom and a mouse model in vivo, and was applied to human oral cavity. Information of surface morphology and vasculature, and under-surface layered structure and birefringence of the oral cavity tissues was obtained. These results showed feasibility of this multimodal imaging system as a tool for studying oral cavity lesions in clinical applications.
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