Evidence map›Paper›PMID 25780739›Full record

ArticleBiomedical optics express2015

High-throughput multiphoton-induced three-dimensional ablation and imaging for biotissues.

Chun-Yu Lin, Pei-Kao Li, Li-Chung Cheng, Yi-Cheng Li, Chia-Yuan Chang, Ann-Shyn Chiang, Chen Yuan Dong, Shean-Jen Chen

Open access · goldAbstract read
In one paragraph

Article in Biomedical optics express, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Chun-Yu LinDepartment of Engineering Science, National Cheng Kung University, Tainan 701, Taiwan.
Pei-Kao LiDepartment of Engineering Science, National Cheng Kung University, Tainan 701, Taiwan.
Li-Chung ChengDepartment of Photonics, National Cheng Kung University, Tainan 701, Taiwan.
Yi-Cheng LiDepartment of Photonics, National Cheng Kung University, Tainan 701, Taiwan.
Chia-Yuan ChangDepartment of Photonics, National Cheng Kung University, Tainan 701, Taiwan.
Ann-Shyn ChiangBrain Research Center, National Tsing Hua University, Hsinchu 300, Taiwan ; Institute of Biotechnology and Department of Life Science, National Tsing Hua University, Hsinchu 300, Taiwan ; aschiang@life.nthu.edu.tw.
Chen Yuan DongDepartment of Physics, National Taiwan University, Taipei 106, Taiwan ; cydong@phys.ntu.edu.tw.
Shean-Jen ChenDepartment of Engineering Science, National Cheng Kung University, Tainan 701, Taiwan ; Center for Micro/Nano Science and Technology, National Cheng Kung University, Tainan 701, Taiwan ; Advanced Optoelectronic Technology Center, National Cheng Kung University, Tainan 701, Taiwan.
National Cheng Kung University · TWNational Taiwan University · TWNational Tsing Hua University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, a temporal focusing-based high-throughput multiphoton-induced ablation system with axially-resolved widefield multiphoton excitation has been successfully applied to rapidly disrupt biotissues. Experimental results demonstrate that this technique features high efficiency for achieving large-area laser ablation without causing serious photothermal damage in non-ablated regions. Furthermore, the rate of tissue processing can reach around 1.6 × 10(6) μm(3)/s in chicken tendon. Moreover, the temporal focusing-based multiphoton system can be efficiently utilized in optical imaging through iterating high-throughput multiphoton-induced ablation machining followed by widefield optical sectioning; hence, it has the potential to obtain molecular images for a whole bio-specimen.

Indexed as

(140.3390) Laser materials processing(170.1020) Ablation of tissue(190.4180) Multiphoton processes

Identifiers

PMID25780739
PMCPMC4354595
OpenAlexW2076786047

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.