Evidence map›Paper›PMID 25780629›Full record

ArticleJournal of pharmacopuncture2012

Effect of Egg White Combined with Chalcanthite on Lipopolysaccharide induced Inflammatory Cytokine Expression in RAW 264.7 cells.

Eun-A Choi, Jeung-Won Yoon, Hak-Joo Choi, Dong-Hee Kim, Hwa-Seung Yoo

Open access · diamondAbstract read
In one paragraph

Article in Journal of pharmacopuncture, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 84% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Eun-A ChoiEast-West Cancer Center, Dunsan Oriental Hospital of Daejeon University, Daejeon, Korea.
Jeung-Won YoonEast-West Cancer Center, Dunsan Oriental Hospital of Daejeon University, Daejeon, Korea.
Hak-Joo ChoiTraditional and Biomedical Research Center, Daejeon University, Daejeon, Korea.
Dong-Hee KimTraditional and Biomedical Research Center, Daejeon University, Daejeon, Korea.
Hwa-Seung YooEast-West Cancer Center, Dunsan Oriental Hospital of Daejeon University, Daejeon, Korea.
Daejeon University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimHistorically, mineral compound herbal medicines have long been used in treatments of immune-related diseases in Korea, China and other Asian countries. In this study, we investigated the anti-inflammatory effect of egg white combined with chalcanthite (IS4) on lipopolysaccharide (LPS)-stimulated RAW 264.7 cells.

methodsRAW 264.7 cells cultured with LPS and various concentrations of IS4 were analyzed to determine the production of pro-inflammatory cytokines and mediators by using enzyme-linked immune sorbent assays (ELISAs).

resultsIS4 concentration inhibited the production of interleukin-1beta (IL-1 β), interleukin-6 (IL-6), and granulocyte -macrophage colony-stimulating factor (GM-CSF) induced by LPS. IS4 at high concentrations (25 and 50㎍/ml) inhibited, in concentration-dependent manner, the expression of tumor necrosis factor-alpha (TNF- α) stimulated by LPS.

conclusionIS4 has shown an anti-inflammatory effect in RAW 264.7 cells.

Indexed as

cytokineGM-CSFIL-1βIL-6lipopolysaccharideTNF–α

Identifiers

PMID25780629
PMCPMC4331931
OpenAlexW2165639049

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.