Evidence map›Paper›PMID 25780611›Full record

ArticleCanadian journal of kidney health and disease2014

The three-year incidence of major hemorrhage among older adults initiating chronic dialysis.

Manish M Sood, Sarah E Bota, Eric McArthur, Moira K Kapral, Navdeep Tangri, Greg Knoll, Deborah Zimmerman, Amit X Garg

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Canadian journal of kidney health and disease, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Non-vitamin K antagonist oral anticoagulants in atrial fibrillation patients with advanced chronic kidney and liver diseases.European heart journal supplements : journal of the European Society of Cardiology · 2022
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. The Risk of Major Hemorrhage with CKD.Journal of the American Society of Nephrology : JASN · 2016
    Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 1 country.

Manish M SoodOttawa Hospital Research Institute, Department of Medicine, University of Ottawa, Ottawa Institute for Clinical Evaluative Sciences, Civic campus, 2-014 Administrative Services Building, 1053 Carling Avenue, Box 693, Ottawa, ON Canada.
Sarah E BotaInstitute for Clinical Evaluative Sciences, Toronto, ON Canada ; Department of Epidemiology and Biostatistics, Western University, London, ON Canada.
Eric McArthurInstitute for Clinical Evaluative Sciences, Toronto, ON Canada.
Moira K KapralInstitute for Clinical Evaluative Sciences, Toronto, ON Canada ; Department of Medicine, University of Toronto, Toronto, ON Canada ; The Institute of Health Policy Management and Evaluation, University of Toronto, Toronto, ON Canada.
Navdeep TangriSeven Oaks General Hospital, Winnipeg, MB, Ontario Canada.
Greg KnollOttawa Hospital Research Institute, Department of Medicine, University of Ottawa, Ottawa Institute for Clinical Evaluative Sciences, Civic campus, 2-014 Administrative Services Building, 1053 Carling Avenue, Box 693, Ottawa, ON Canada.
Deborah ZimmermanOttawa Hospital Research Institute, Department of Medicine, University of Ottawa, Ottawa Institute for Clinical Evaluative Sciences, Civic campus, 2-014 Administrative Services Building, 1053 Carling Avenue, Box 693, Ottawa, ON Canada.
Amit X GargInstitute for Clinical Evaluative Sciences, Toronto, ON Canada ; Department of Epidemiology and Biostatistics, Western University, London, ON Canada ; Kidney Clinical Research Unit, Division of Nephrology, Western University, London, ON Canada ; Division of Nephrology, Department of Medicine, Western University, London, ON Canada.
Institute for Clinical Evaluative Sciences · CAOttawa Hospital · CASeven Oaks General Hospital · CAUniversity of Ottawa · CAUniversity of Toronto · CAWestern University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFor those who initiate chronic dialysis, knowing what proportion will experience 3-year outcomes of hemorrhage with hospitalization informs patient prognosis, disease impact, and the planning of trials and programs to prevent events.

objectivesWe examined the incidence of hemorrhage and related gastrointestinal endoscopic procedures in incident older dialysis patients and stratified patients by age, era, dialysis modality and whether recently prescribed anti-thrombotic medication.

designRetrospective cohort study.

settingOntario, Canada from 1998 to 2008 (n = 11,173). PATIENTS: All older patients (>65 years) who initiated chronic dialysis. MEASUREMENTS: Hospitalization with hemorrhage and its subtypes (upper and lower gastrointestinal, intra-cerebral, subarachnoid) and related-gastrointestinal procedures.

methodsThree-year outcomes of hospitalization with hemorrhage were expressed as cumulative incidence and incidence rate (number of events per 1,000 patient years). Results were stratified by patient age (66 to 74, 75 to 84, ≥ 85), era (1998 to 2001, 2002 to 2005, 2006 to 2008) and dialysis modality. Among those with hemorrhage, we examined prescriptions for anti-thrombotic medications (warfarin, clopidogrel) in the preceding 120 days.

resultsThe 3-year cumulative incidence of hemorrhage was 14.4% (roughly 1 in 7 patients). By location, the 3-year cumulative incidence was 8.9% lower gastrointestinal, 6.1% upper gastrointestinal, 0.9% intra-cerebral and 0.1% sub arachnoid hemorrhage. The 3-year cumulative incidence of gastrointestinal endoscopic procedures was 14.8%. The cumulative incidence and rate of hemorrhage were not appreciably different across the 3 age strata, by era or by dialysis modality. Among patients with a hemorrhage, 29.5% were prescribed warfarin in the preceding 120 days, and 8.4% clopidogrel. LIMITATIONS: Recurrent events were not included.

conclusionsMany older patients who initiate chronic dialysis will be hospitalized with hemorrhage and receive related procedures over the subsequent three years. Despite greater age and co-morbidity over the last decade this incidence has not changed.

Identifiers

PMID25780611
PMCPMC4349720
OpenAlexW2101560931

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.