Evidence map›Paper›PMID 25780583›Full record

ArticleBasic and clinical andrology2014

Beneficial effects of varicocele embolization on semen parameters.

Julie Prasivoravong, François Marcelli, Laurent Lemaître, Pascal Pigny, Nassima Ramdane, Marie-Claire Peers, Valérie Mitchell, Jean-Marc Rigot

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Basic and clinical andrology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
4.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Effects of varicocelectomy on serum testosterone.Translational andrology and urology · 2016
    Review
  12. Varicocele: A Review.Seminars in interventional radiology · 2016
    Review
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Julie PrasivoravongDepartment of Andrology, Lille University Hospital, Lille Cedex, France ; Department of Andrology, CHRU Lille, Hôpital Calmette, Boulevard du Professeur Leclercq, 59037 Lille Cedex, France.
François MarcelliDepartment of Andrology, Lille University Hospital, Lille Cedex, France.
Laurent LemaîtreDepartment of Radiology, Lille University Hospital, Lille Cedex, France.
Pascal PignyDepartment of Biochemistry and Molecular Biology, Lille University Hospital, Lille Cedex, France.
Nassima RamdaneDepartment of Biostatistics, Lille University Hospital, Lille Cedex, France.
Marie-Claire PeersBiology of Reproduction Unit, Lille University Hospital, Lille Cedex, France.
Valérie MitchellBiology of Reproduction Unit, Lille University Hospital, Lille Cedex, France ; EA4308 Gametogenesis and Gamete Quality, University of Lille, Lille Cedex, France.
Jean-Marc RigotDepartment of Andrology, Lille University Hospital, Lille Cedex, France ; EA4308 Gametogenesis and Gamete Quality, University of Lille, Lille Cedex, France.
Université de Lille · FRLille’s Cardiology Hospital · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe value of varicocele repair and the latter's impact on semen parameters are still subject to debate.

methodsWe analyse changes over time in initially abnormal sperm parameters and serum concentrations of testosterone, FSH and inhibin B after embolization treatment of males with high-grade varicocele. From 2007 to 2012, we recruited 47 male infertile patients with clinically visible left varicocele in the resting patient and at least one abnormal semen parameter. Sperm parameters and serum levels of total testosterone, FSH and inhibin B were measured prior to retrograde embolization (M0) and then 3 (M3) and 6 (M6) months afterwards.

resultsAt M0, the median sperm concentration was 5.78 [0.84-37.70] × 10(6)/ejaculate. The mean ± SD sperm progressive motility, vitality and percentage of normal sperm were respectively, 21.83 ± 16.48%, 61.88 ± 15.98% and 12.88 ± 7.15%. The corresponding values at M3 were significantly higher (38.75 [3.96-95] × 10(6)/ejaculate, 29.32 ± 14.21%, 69.14 ± 14.86% and 19.03 ± 11.02%, respectively). The mean percentage of spermatozoa with a thin head was significantly lower at M6 (6.35 ± 5.29%) than at M0 (14.03 ± 13.09%). The mean serum testosterone, FSH and inhibin B levels did not change significantly over time.

conclusionsEmbolization treatment in men with clinically visible left varicocele, abnormal sperm parameters and documented infertility is associated with a significant improvement in semen parameters including sperm head morphology.

Indexed as

EmbolizationFSHInhibin BSperm parametersVaricocele

Identifiers

PMID25780583
PMCPMC4349315
OpenAlexW2012971197

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.