ReviewBiology of sex differences2014
NIH initiative to balance sex of animals in preclinical studies: generative questions to guide policy, implementation, and metrics.
Review in Biology of sex differences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
62 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Deciphering the sex bias in housekeeping gene expression in adipose tissue: a comprehensive meta-analysis of transcriptomic studies.Biology of sex differences · 2023Pooled it
- Importance of Systematic Reviews and Meta-analyses of Animal Studies: Challenges for Animal-to-Human Translation.Journal of the American Association for Laboratory Animal Science : JAALAS · 2020Pooled it
- Reporting of sex as a variable in cardiovascular studies using cultured cells: A systematic review.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Pooled it
- Sex differences in nicotine intravenous self-administration: A meta-analytic review.Physiology & behavior · 2019Pooled it
- Sex Differences in Severity of Stroke in the INSTRUCT Study: a Meta-Analysis of Individual Participant Data.Journal of the American Heart Association · 2019Pooled it
- Sex differences in nucleus accumbens circuitry engaged with binge-like ethanol drinking.Psychopharmacology · 2026Article
- Sex Differences in Dietary-Induced Liver Steatosis and Insulin Receptor-Related Signaling in Aged Mice Lacking Serotonin Transporter.International journal of molecular sciences · 2026Article
- Sex and the Developmental Environment Shape Molecular Networks Underlying Bronchial Responsiveness in Mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Functional Integration of Different-Sex Gonad Transplants Into the Adult Mouse Hypothalamic Pituitary Gonadal Axis.Advanced biology · 2026Article
- Current Understanding of Sex Differences in Metal-Induced Diseases.Current environmental health reports · 2025Review
- Exploring heterogeneity: a dive into preclinical models of cancer cachexia.American journal of physiology. Cell physiology · 2024Review
- The Influence of BMP6 on Serotonin and Glucose Metabolism.International journal of molecular sciences · 2024Article
- Dissolving sodium hydrosulfide in drinking water is not a good source of hydrogen sulfide for animal studies.Scientific reports · 2023Article
- Knockout or inhibition of USP30 protects dopaminergic neurons in a Parkinson's disease mouse model.Nature communications · 2023Article
- Streptozotocin as a tool for induction of rat models of diabetes: a practical guide.EXCLI journal · 2023Review
- Sex specificity of pancreatic cancer cachexia phenotypes, mechanisms, and treatment in mice and humans: role of Activin.Journal of cachexia, sarcopenia and muscle · 2022Article
- Regulation of alcohol drinking by ventral striatum and extended amygdala circuitry.Neuropharmacology · 2022Review
- Effects of Early Life Exposure to Sex Hormones on Neurochemical and Behavioral Responses to Psychostimulants in Adulthood: Implications in Drug Addiction.International journal of molecular sciences · 2022Article
- Combined cART including Tenofovir Disoproxil, Emtricitabine, and Dolutegravir has potent therapeutic effects in HIV-1 infected humanized mice.Journal of translational medicine · 2021Article
- Biomedical Researchers' Perceptions of the NIH's Sex as a Biological Variable Policy for Animal Research: Results from a U.S. National Survey.Journal of women's health (2002) · 2021Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
In May of 2014, the NIH Director together with the Director of the Office of Research on Women's Health announced plans to take a multi-dimensional approach to address the over reliance on male cells and animals in preclinical research. The NIH is engaging the scientific community in the development of policies to improve the sex balance in research. The present, past, and future presidents of the Organization for the Study of Sex Differences, in order to encourage thoughtful discussion among scientists, pose a series of questions to generate ideas in three areas: 1. research strategies, 2. educational strategies, and 3. strategies to monitor effectiveness of policies to improve the sex balance in research. By promoting discussion within the scientific community, a consensus will evolve that will move science forward in a productive and effective manner.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.