Evidence map›Paper›PMID 25780554›Full record

ArticleMethods in ecology and evolution2015

Simultaneously estimating evolutionary history and repeated traits phylogenetic signal: applications to viral and host phenotypic evolution.

Bram Vrancken, Philippe Lemey, Andrew Rambaut, Trevor Bedford, Ben Longdon, Huldrych F Günthard, Marc A Suchard

Open access · bronzeAbstract read
In one paragraph

Article in Methods in ecology and evolution, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Phylogenetic Factor Analysis.Systematic biology · 2018
    Article
  13. Article
  14. Review
  15. Phylodynamic applications in 21Global health research and policy · 2017
    Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 7 institutions in 4 countries.

Bram VranckenDepartment of Microbiology and Immunology, Rega Institute, KU Leuven - University of Leuven, Leuven, Belgium.
Philippe LemeyDepartment of Microbiology and Immunology, Rega Institute, KU Leuven - University of Leuven, Leuven, Belgium.
Andrew RambautInstitute of Evolutionary Biology, University of Edinburgh, Edinburgh, UK ; Fogarty International Center, National Institutes of Health, Bethesda, MD, USA.
Trevor BedfordVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Ben LongdonDepartment of Genetics, University of Cambridge, Cambridge, UK.
Huldrych F GünthardDivision of Infectious Diseases and Hospital Epidemiology, University Hospital of Zürich, University of Zürich, Zürich, Switzerland.
Marc A SuchardDepartments of Biomathematics and Human Genetics, David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA 90095-1766, USA ; Department of Biostatistics, UCLA Fielding School of Public Health, University of California, Los Angeles, CA 90095-1766, USA.
Fred Hutch Cancer Center · USKU Leuven · BENational Institutes of Health · USRega Institute for Medical Research · BEUniversity of California, Los Angeles · USUniversity of Cambridge · GBUniversity of Zurich · CH

Funding

Genomics, GPUs, and Next Generation Computational StatisticsR01HG006139 · NHGRI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SOBEL, ERIC · 2011 to 2023
$5.1M
BAYESIAN MODELING AND DATA INTEGRATION IN INFECTIOUS DISEASE PHYLODYNAMICSR01AI107034 · NIAID · UNIVERSITY OF WASHINGTON · PI MININ, VOLODYMYR · 2013 to 2017
$1.7M
NHGRI NIH HHS R01 HG006139NIAID NIH HHS R01 AI107034Wellcome Trust 095831
6 · The paper itself

Abstract

Phylogenetic signal quantifies the degree to which resemblance in continuously-valued traits reflects phylogenetic relatedness. Measures of phylogenetic signal are widely used in ecological and evolutionary research, and are recently gaining traction in viral evolutionary studies. Standard estimators of phylogenetic signal frequently condition on data summary statistics of the repeated trait observations and fixed phylogenetics trees, resulting in information loss and potential bias. To incorporate the observation process and phylogenetic uncertainty in a model-based approach, we develop a novel Bayesian inference method to simultaneously estimate the evolutionary history and phylogenetic signal from molecular sequence data and repeated multivariate traits. Our approach builds upon a phylogenetic diffusion framework that model continuous trait evolution as a Brownian motion process and incorporates Pagel's

Indexed as

adaptationBayesian phylogeneticscomparative approachvirulencevirus evolution

Identifiers

PMID25780554
PMCPMC4358766
OpenAlexW2103273267

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.