Evidence map›Paper›PMID 25780535›Full record

ArticleIranian journal of cancer prevention2012

Human papilloma virus in head and neck squamous cell cancer.

I Asvadi Kermani, S H Seifi, R Dolatkhah, E Sakhinia, S Dastgiri, A Ebrahimi, A Lotfy, H A Esmaeili, Mohammadi G, Naderpour M and 3 more

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PubMed Full text at PMC
In one paragraph

Article in Iranian journal of cancer prevention, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

I Asvadi KermaniHaematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
S H SeifiHaematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
R DolatkhahHaematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
E SakhiniaDept. of Biochemistry, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
S DastgiriDept. of Social Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
A EbrahimiHaematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
A LotfyDept. of ENT, Tabriz University of Medical Sciences, Tabriz, Iran.
H A EsmaeiliDept. of Pathology, Tabriz University of Medical Sciences, Tabriz, Iran.
Mohammadi GDept. of ENT, Tabriz University of Medical Sciences, Tabriz, Iran.
Naderpour MDept. of ENT, Tabriz University of Medical Sciences, Tabriz, Iran.
Hajalipour ShDept. of ENT, Tabriz University of Medical Sciences, Tabriz, Iran.
Asghari Haggi AHaematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Nadri MHaematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Tabriz University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEpidemiologic and molecular evidences have established a strong link between high risk types of Human Papilloma Virus and a subgroup of Head and Neck Squamous Cell Carcinomas (HNSCC). We evaluated the frequency of HPV positivity in HNSCC and its relationship to demographic and some risk factor variables in an open case- control study.

methodsFourteen recently diagnosed patients with squamous cell cancer of oropharynx, hypopharynx and larynx aged 18-50 years were examined from 2008-2010 in Tabriz, Iran. HPV DNA was extracted from paraffin-embedded blocks of each patient's sample for PCR evaluation. Saliva samples of 94 control cancer-free subjects were collected for DNA analysis. Multivariable logistic regression method was used to calculate odds ratio for case-control comparisons.

resultsHigh risk HPV was detected in 6(42.8%) patients, and 6(5.3%) control subjects which was statistically significant (p<0.0001). HPV-18 was the most frequent type both in the cases and controls. HPV-16 DNA was detected in two patients of the case group, but it was not detected in any of the controls. The relation between demographic and risk factor variables was not statistically significant.

conclusionHPV infection has a significant impact on HNSCC. Despite HPV-16 stronger impact, HPV-18 is more likely to cause malignant degeneration in such cancers amongst some communities. It is vital to introduce and conduct immunization schedules in health care systems to protect communities to some extent.

Indexed as

Head and Neck NeoplasmsHuman Papilloma Virus 16Human Papilloma Virus 18SexSquamous Cell Carcinoma

Identifiers

PMID25780535
PMCPMC4352522
OpenAlexW2140137699

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.