Evidence map›Paper›PMID 25780408›Full record

ArticleExperimental and therapeutic medicine2015

Mesenchymal stem cells expressing interleukin-18 suppress breast cancer cells

Xiaoyi Liu, Jianxia Hu, Suyuan Sun, Funian Li, Weihong Cao, Y U Wang, Zhongliang Ma, Zhigang Yu

Erratum issuedOpen access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental and therapeutic medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 48 citations in OpenAlex.

  1. Review
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  6. Article
  7. Interleukin gene delivery for cancer gene therapy:Iranian journal of basic medical sciences · 2023
    Review
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  19. Article
  20. The contrasting roles of inflammasomes in cancer.American journal of cancer research · 2018
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Xiaoyi LiuDepartment of Galactophore, The Second Hospital of Shandong University, Jinan, Shandong 250033, P.R. China ; Department of Galactophore, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, P.R. China.
Jianxia HuStem Cell Research Center, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, P.R. China.
Suyuan SunDepartment of Galactophore, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, P.R. China.
Funian LiDepartment of Galactophore, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, P.R. China.
Weihong CaoDepartment of Galactophore, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, P.R. China.
Y U WangDepartment of Galactophore, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, P.R. China.
Zhongliang MaDepartment of Galactophore, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, P.R. China.
Zhigang YuDepartment of Galactophore, The Second Hospital of Shandong University, Jinan, Shandong 250033, P.R. China.
Affiliated Hospital of Qingdao University · CNQingdao University · CNSecond Hospital of Shandong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast cancer is the most common malignancy among females throughout the world. Current treatments have unsatisfactory outcomes due to the dispersed nature of certain types of the disease. The development of a more effective therapy for breast cancer has long been one of the most elusive goals of cancer gene therapy. In the present study, human mesenchymal stem cells derived from umbilical cord (hUMSCs) genetically modified with interleukin 18 (IL-18) gene were used to study the effect of hUMSCs/IL-18 on the growth, migration and invasion of MCF-7 and HCC1937 cells

Indexed as

breast cancercancer gene therapygene transductioninterleukin-18mesenchymal stem cell

Identifiers

PMID25780408
PMCPMC4353741
OpenAlexW2032525691

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.