Evidence map›Paper›PMID 25780339›Full record

ArticleInfectious diseases2015

Lack of Correlation between Bristol Stool Scale and Quantitative Bacterial Load in Clostridium difficile Infection.

Abrar K Thabit, David P Nicolau

Abstract read
In one paragraph

Article in Infectious diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Abrar K ThabitCenter for Anti-infective Research and Development, Hartford Hospital, Hartford, CT, USA.
David P NicolauCenter for Anti-infective Research and Development, Hartford Hospital, Hartford, CT, USA. ; Division of Infectious Diseases, Hartford Hospital, Hartford, CT, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Decision to test for Clostridium difficile infection (CDI) is usually made when patients have loose stools with Bristol stool score of ≥5. We aimed to assess the relationship between bacterial load of C. difficile and Bristol stool scale, as well as stool frequency in stool samples collected from patients infected with the organism. Samples were collected at baseline, during therapy, and at the end of therapy. Spearman correlation test was used to evaluate these relationships. No correlation between Bristol stool scale and fecal load of C. difficile was found for both spores and vegetative cells at all time points as counts were persistently high (P = non-significant). Weak positive correlations were found between stool frequency and fecal load of C. difficile spores and vegetative cells (r s = 0.22 and 0.24, P = 0.04 and 0.03, respectively). These findings indicate that quantitative colony counts were sufficiently high to detect C. difficile, irrespective of stool consistency, and suggest that semiformed stool should be sought for the pathogen in symptomatic patients with frequent stools.

Indexed as

Bristol stool scaleClostridium difficilefecal loadsporesvegetative cells

Identifiers

PMID25780339
PMCPMC4346303

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.