Evidence map›Paper›PMID 25780311›Full record

SynthesisWorld journal of gastroenterology2015

Nonselective beta-blockers in cirrhotic patients with no or small varices: A meta-analysis.

Xing-Shun Qi, Yong-Xin Bao, Ming Bai, Wen-Da Xu, Jun-Na Dai, Xiao-Zhong Guo

Abstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in World journal of gastroenterology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  4. Pooled it
  5. Guideline
  6. Pooled it
  7. Article
  8. Article
  9. Review
  10. Article
  11. [Guidelines on the management of esophagogastric variceal bleeding in cirrhotic portal hypertension].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2022
    Article
  12. Article
  13. Review
  14. Review
  15. Update on the management of gastrointestinal varices.World journal of gastrointestinal pharmacology and therapeutics · 2019
    Review
  16. Review
  17. Prevention and management of gastroesophageal varices.Clinical and molecular hepatology · 2018
    Review
  18. Article
  19. Efficacy and Time Sensitivity of Amniotic Membrane treatment in Patients with Diabetic Foot Ulcers: A Systematic Review and Meta-analysis.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2017
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xing-Shun QiXing-Shun Qi, Wen-Da Xu, Jun-Na Dai, Xiao-Zhong Guo, Liver cirrhosis group, Department of Gastroenterology, General Hospital of Shenyang Military Area, Shenyang 110840, Liaoning Province, China.
Yong-Xin BaoXing-Shun Qi, Wen-Da Xu, Jun-Na Dai, Xiao-Zhong Guo, Liver cirrhosis group, Department of Gastroenterology, General Hospital of Shenyang Military Area, Shenyang 110840, Liaoning Province, China.
Ming BaiXing-Shun Qi, Wen-Da Xu, Jun-Na Dai, Xiao-Zhong Guo, Liver cirrhosis group, Department of Gastroenterology, General Hospital of Shenyang Military Area, Shenyang 110840, Liaoning Province, China.
Wen-Da XuXing-Shun Qi, Wen-Da Xu, Jun-Na Dai, Xiao-Zhong Guo, Liver cirrhosis group, Department of Gastroenterology, General Hospital of Shenyang Military Area, Shenyang 110840, Liaoning Province, China.
Jun-Na DaiXing-Shun Qi, Wen-Da Xu, Jun-Na Dai, Xiao-Zhong Guo, Liver cirrhosis group, Department of Gastroenterology, General Hospital of Shenyang Military Area, Shenyang 110840, Liaoning Province, China.
Xiao-Zhong GuoXing-Shun Qi, Wen-Da Xu, Jun-Na Dai, Xiao-Zhong Guo, Liver cirrhosis group, Department of Gastroenterology, General Hospital of Shenyang Military Area, Shenyang 110840, Liaoning Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo explore effects of nonselective beta-blockers (NSBBs) in cirrhotic patients with no or small varices.

methodsThe PubMed, EMBASE, Science Direct, and Cochrane library databases were searched for relevant papers. A meta-analysis was performed using ORs with 95%CI as the effect sizes. Subgroup analysis was conducted according to the studies including patients without varices and those with small varices.

resultsOverall, 784 papers were initially retrieved from the database searches, of which six randomized controlled trials were included in the meta-analysis. The incidences of large varices development (OR = 1.05, 95%CI: 0.25-4.36; P = 0.95), first upper gastrointestinal bleeding (OR = 0.59, 95%CI: 0.24-1.47; P = 0.26), and death (OR = 0.70, 95%CI: 0.45-1.10; P = 0.12) were similar between NSBB and placebo groups. However, the incidence of adverse events was significantly higher in the NSBB group compared with the placebo group (OR = 3.47, 95%CI: 1.45-8.33; P = 0.005). The results of subgroup analyses were similar to those of overall analyses.

conclusionThe results of this meta-analysis indicate that NSBBs should not be recommended for cirrhotic patients with no or small varices.

Indexed as

Adrenergic beta-AntagonistsAdultAgedChi-Square DistributionEsophageal and Gastric VaricesFemaleGastrointestinal HemorrhageHumansLiver CirrhosisMaleMiddle AgedOdds RatioPatient SelectionRisk FactorsTreatment OutcomeAdrenergic beta-AntagonistsBeta-blockerLiver cirrhosisPortal hypertensionVariceal bleedingVarices

Identifiers

PMID25780311
PMCPMC4356933

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.