Evidence map›Paper›PMID 25780303›Full record

ArticleWorld journal of gastroenterology2015

C-arm Lipiodol CT in transcatheter arterial chemoembolization for small hepatocellular carcinoma.

Jian-Jun Li, Jia-Sheng Zheng, Shi-Chang Cui, Xiong-Wei Cui, Cai-Xia Hu, Da Fang, Lin-Chao Ye

Open access · hybridAbstract read
In one paragraph

Article in World journal of gastroenterology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jian-Jun LiJian-Jun Li, Jia-Sheng Zheng, Shi-Chang Cui, Xiong-Wei Cui, Cai-Xia Hu, Da Fang, Oncology and Hepatobiliary Minimally Invasive Interventional Center, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
Jia-Sheng ZhengJian-Jun Li, Jia-Sheng Zheng, Shi-Chang Cui, Xiong-Wei Cui, Cai-Xia Hu, Da Fang, Oncology and Hepatobiliary Minimally Invasive Interventional Center, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
Shi-Chang CuiJian-Jun Li, Jia-Sheng Zheng, Shi-Chang Cui, Xiong-Wei Cui, Cai-Xia Hu, Da Fang, Oncology and Hepatobiliary Minimally Invasive Interventional Center, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
Xiong-Wei CuiJian-Jun Li, Jia-Sheng Zheng, Shi-Chang Cui, Xiong-Wei Cui, Cai-Xia Hu, Da Fang, Oncology and Hepatobiliary Minimally Invasive Interventional Center, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
Cai-Xia HuJian-Jun Li, Jia-Sheng Zheng, Shi-Chang Cui, Xiong-Wei Cui, Cai-Xia Hu, Da Fang, Oncology and Hepatobiliary Minimally Invasive Interventional Center, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
Da FangJian-Jun Li, Jia-Sheng Zheng, Shi-Chang Cui, Xiong-Wei Cui, Cai-Xia Hu, Da Fang, Oncology and Hepatobiliary Minimally Invasive Interventional Center, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
Lin-Chao YeJian-Jun Li, Jia-Sheng Zheng, Shi-Chang Cui, Xiong-Wei Cui, Cai-Xia Hu, Da Fang, Oncology and Hepatobiliary Minimally Invasive Interventional Center, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
Capital Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo investigate the value of C-arm Lipiodol computed tomography (CT) for intra-procedural hepatocellular carcinoma (HCC) lesion detection during transcatheter arterial chemoembolization (TACE).

methodsForty patients (37 male, 3 female; mean age, 52.6 ± 12.5 years, age range: 25-82 years) diagnosed with HCC were enrolled in this study. All patients underwent 64-slice CT 1-2 wk before TACE. During the procedure, hepatic angiography was performed first. Following diagnostic embolization with Lipiodol injected into the hepatic artery, a C-arm CT scan was immediately conducted (C-arm Lipiodol CT). If new HCC lesions were confirmed, gelfoam particles were super-selectively injected into the tumor-nourishing blood vessel. A Lipiodol CT scan was performed 7-14 d after TACE. All images acquired from 64-slice CT, digital subtraction angiography (DSA), C-arm Lipiodol CT and Lipiodol CT were retrospectively reviewed by four radiologists and the number of detected lesions in each examination was counted, respectively. The results of Lipiodol CT were taken as the diagnostic reference. Alpha-fetoprotein values were examined both before and after TACE. This study only takes into account the lesions that were not found or were considered suspicious on 64-slice CT before TACE.

resultsPreprocedural 64-slice CT detected a total of 13 suspicious lesions in the 40 patients. DSA detected ten definite and four suspicious lesions. C-arm Lipiodol CT detected 71 lesions in total and Lipiodol CT confirmed 67 lesions with a diameter range of 3-12 mm. Four false-positive lesions, which were detected by C-arm Lipiodol CT, were considered to be hepatic artery-portal vein fistulas. The average alpha-fetoprotein values before and after TACE were significantly different (452.3 ± 192.6 ng/mL vs 223.8 ± 93.2 ng/mL; P = 0.039).

conclusionC-arm Lipiodol CT has a higher diagnostic sensitivity for small HCC lesions. This technique may help physicians make intraprocedural decisions to provide patients with earlier treatment.

Indexed as

Contrast MediaEthiodized OilMultidetector Computed TomographyAdultAgedAged, 80 and overalpha-FetoproteinsAngiography, Digital SubtractionCarcinoma, HepatocellularChemoembolization, TherapeuticEarly Detection of CancerFalse Positive ReactionsFemaleHumansLiver NeoplasmsMaleAFP protein, humanalpha-FetoproteinsContrast MediaEthiodized OilAngiographyC-arm computed tomographyChemoembolizationDigital subtractionHepatocellular CarcinomaLipiodolTherapeutic

Identifiers

PMID25780303
PMCPMC4356925
OpenAlexW2332877842

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.