Evidence map›Paper›PMID 25780298›Full record

ArticleWorld journal of gastroenterology2015

Clinical outcome of medium-sized hepatocellular carcinoma treated with microwave ablation.

Ai-Xue Sun, Zhi-Li Cheng, Pan-Pan Wu, Yue-Hong Sheng, Xiu-Juan Qu, Wen Lu, Cheng-Gong Zhao, Guo-Jun Qian

Abstract read
In one paragraph

Article in World journal of gastroenterology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  4. [Curative effect of percutaneous microwave ablation therapy on hepatocellular carcinoma survival: a 15-year real-world study].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2024
    Article
  5. [Guidelines for image-guided ablation of primary liver cancer (2023 version)].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2024
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  16. Observational
  17. Article
  18. Microwave ablation in primary and secondary liver tumours: technical and clinical approaches.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2017
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ai-Xue SunAi-Xue Sun, Zhi-Li Cheng, Cheng-Gong Zhao, Department of General Surgery, 105 Hospital of Chinese PLA, Hefei 230031, Anhui Province, China.
Zhi-Li ChengAi-Xue Sun, Zhi-Li Cheng, Cheng-Gong Zhao, Department of General Surgery, 105 Hospital of Chinese PLA, Hefei 230031, Anhui Province, China.
Pan-Pan WuAi-Xue Sun, Zhi-Li Cheng, Cheng-Gong Zhao, Department of General Surgery, 105 Hospital of Chinese PLA, Hefei 230031, Anhui Province, China.
Yue-Hong ShengAi-Xue Sun, Zhi-Li Cheng, Cheng-Gong Zhao, Department of General Surgery, 105 Hospital of Chinese PLA, Hefei 230031, Anhui Province, China.
Xiu-Juan QuAi-Xue Sun, Zhi-Li Cheng, Cheng-Gong Zhao, Department of General Surgery, 105 Hospital of Chinese PLA, Hefei 230031, Anhui Province, China.
Wen LuAi-Xue Sun, Zhi-Li Cheng, Cheng-Gong Zhao, Department of General Surgery, 105 Hospital of Chinese PLA, Hefei 230031, Anhui Province, China.
Cheng-Gong ZhaoAi-Xue Sun, Zhi-Li Cheng, Cheng-Gong Zhao, Department of General Surgery, 105 Hospital of Chinese PLA, Hefei 230031, Anhui Province, China.
Guo-Jun QianAi-Xue Sun, Zhi-Li Cheng, Cheng-Gong Zhao, Department of General Surgery, 105 Hospital of Chinese PLA, Hefei 230031, Anhui Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo evaluate the outcomes of patients with medium-sized hepatocellular carcinoma (HCC) who underwent percutaneous microwave ablation (MWA).

methodsWe retrospectively reviewed all patients with a single medium-sized HCC who underwent percutaneous MWA from January 2010 to January 2013. Technical success, technical effectiveness and complications were subsequently observed. Survival curves were constructed using the Kaplan-Meier method. The Cox proportional hazards model was fitted to each variable. The relative prognostic significance of the variables for predicting overall survival rate, recurrence-free survival rate and local tumor recurrence(s) was assessed using univariate analysis. All variables with a P value < 0.20 were subjected to multivariate analysis.

resultsThe study included 182 patients (mean age, 58 years; age range: 22-86 years) with a single HCC (mean size, 3.72 ± 0.54 cm; range: 3.02-5.00 cm). The estimated technical effectiveness rate was 93% in 182 patients. The major complication rate was 2.7% (5/182), including liver abscess in 4 cases, and abdominal bleeding at the puncture site in 1 case. Thirty-day mortality rate was 0.5% (1/182). One patient died due to liver abscess-related septicemia. Cumulative recurrence-free survival and overall survival (OS) rates were 51%, 36%, 27% and 89%, 74%, 60% at 1, 2, and 3 years, respectively. Age (P = 0.017) and tumor diameter (P = 0.029) were independent factors associated with local tumor recurrence. None of the factors had a statistically significant impact on recurrence-free survival. Serum albumin level (P = 0.009) and new lesion(s) (P = 0.029) were independently associated with OS.

conclusionPercutaneous MWA is a relatively safe and effective treatment for patients with medium-sized HCC.

Indexed as

Ablation TechniquesAdultAgedAged, 80 and overCarcinoma, HepatocellularDisease-Free SurvivalFemaleHumansKaplan-Meier EstimateLiver NeoplasmsMagnetic Resonance ImagingMaleMicrowavesMiddle AgedMultivariate AnalysisNeoplasm Recurrence, LocalCox analysisHepatocellular carcinomaMedium-sized tumorMicrowave ablationOutcomes

Identifiers

PMID25780298
PMCPMC4356920

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.