ReviewWorld journal of gastroenterology2015
To be or not to be: The host genetic factor and beyond in Helicobacter pylori mediated gastro-duodenal diseases.
Review in World journal of gastroenterology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Association of the IL-1RN variable number of tandem repeat polymorphism and Helicobacter pylori infection: A meta-analysis.PloS one · 2017Pooled it
- Functionally significant polymorphisms of the MMP-9 gene are associated with peptic ulcer disease in the Caucasian population of Central Russia.Scientific reports · 2021Trial
- Beyond Urease: New Potential Enzymatic Targets inACS omega · 2026Review
- Multimodal anti-Helicobacter pylori effects of Lactobacillus casei HY001: Evidence from in vitro and in vivo studies.PloS one · 2026Article
- Clinical Pathologic Profiles ofJournal of clinical medicine · 2025Article
- Inflammatory factors collaboratively linkFrontiers in immunology · 2025Review
- An integrated network analysis, RNA-seq andFrontiers in pharmacology · 2023Article
- Review
- Atractylone Alleviates Ethanol-Induced Gastric Ulcer in Rat with Altered Gut Microbiota and Metabolites.Journal of inflammation research · 2022Article
- Effects of Autologous Platelet-Rich Plasma on Healing of Peptic Ulcers: A Randomized Controlled Trial.Gastroenterology research and practice · 2022Article
- Contribution ofFrontiers in immunology · 2022Article
- Advances in the Aetiology & Endoscopic Detection and Management of Early Gastric Cancer.Cancers · 2021Review
- LowFrontiers in microbiology · 2021Article
- Preventative and Therapeutic Potential of Flavonoids in Peptic Ulcers.Molecules (Basel, Switzerland) · 2020Review
- Peptic Ulcer Disease: A Brief Review of Conventional Therapy and Herbal Treatment Options.Journal of clinical medicine · 2019Review
- Association of a single nucleotide polymorphism in the TLR2 gene (rs3804099), but not in the TLR4 gene (rs4986790), with Helicobacter pylori infection and peptic ulcer.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2018Article
- From inflammation to gastric cancer - the importance of Hedgehog/GLI signaling in Helicobacter pylori-induced chronic inflammatory and neoplastic diseases.Cell communication and signaling : CCS · 2017Review
- Infectious Aetiology of Marginal Zone Lymphoma and Role of Anti-Infective Therapy.Mediterranean journal of hematology and infectious diseases · 2016Review
- Fermented Foods: Are They Tasty Medicines for Helicobacter pylori Associated Peptic Ulcer and Gastric Cancer?Frontiers in microbiology · 2016Review
- Helicobacter pylori in gastric carcinogenesis.World journal of gastrointestinal oncology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Helicobacter pylori (H. pylori) have long been associated with a spectrum of disease outcomes in the gastro-duodenal system. Heterogeneity in bacterial virulence factors or strains is not enough to explain the divergent disease phenotypes manifested by the infection. This review focuses on host genetic factors that are involved during infection and eventually are thought to influence the disease phenotype. We have summarized the different host genes that have been investigated for association studies in H. pylori mediated duodenal ulcer or gastric cancer. We discuss that as the bacteria co-evolved with the host; these host gene also show much variation across different ethnic population. We illustrate the allelic distribution of interleukin-1B, across different population which is one of the most popular candidate gene studied with respect to H. pylori infections. Further, we highlight that several polymorphisms in the pathway gene can by itself or collectively affect the acid secretion pathway axis (gastrin: somatostatin) thereby resulting in a spectrum of disease phenotype.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.