Evidence map›Paper›PMID 25779970›Full record

Trial reportAmerican journal of hematology2015

Gene-centric approach identifies new and known loci for FVIII activity and VWF antigen levels in European Americans and African Americans.

Weihong Tang, Mary Cushman, David Green, Stephen S Rich, Leslie A Lange, Qiong Yang, Russell P Tracy, Geoffrey H Tofler, Saonli Basu, James G Wilson and 12 more

Open access · greenAbstract readClinical TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in American journal of hematology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Thrombotic risk determined byResearch and practice in thrombosis and haemostasis · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. CommonResearch and practice in thrombosis and haemostasis · 2018
    Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 14 institutions in 2 countries.

Weihong TangDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota.
Mary CushmanDepartment of Medicine, University of Vermont, Burlington, Vermont.
David GreenDivision of Hematology/Oncology, Department of Medicine, Feinberg School of Medicine of Northwestern University, Chicago, Illinois.
Stephen S RichDepartment of Public Health Sciences and the Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia.
Leslie A LangeDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Qiong YangDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts.
Russell P TracyDepartment of Pathology, University of Vermont College of Medicine, Burlington, Vermont.
Geoffrey H ToflerDepartment of Cardiology, Royal North Shore Hospital, University of Sydney, Australia.
Saonli BasuDivision of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, Minnesota.
James G WilsonDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi.
Brendan J KeatingDivision of Transplantation, Department of Surgery, University of Pennsylvania, Philadelphia, Pennsylvania.
Lu-Chen WengDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota.
Herman A TaylorDepartment of Medicine, Jackson Heart Study, University of Mississippi Medical Center, Jackson, Mississippi.
David R JacobsDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota.
Joseph A DelaneyDepartment of Epidemiology, University of Washington, Seattle, Washington.
Cameron D PalmerBroad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts.
Taylor YoungBroad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts.
James S PankowDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota.
Christopher J O'DonnellDepartment of Cardiovascular Epidemiology and Human Genomics, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland.
Nicholas L SmithDepartment of Epidemiology, University of Washington, Seattle, Washington.
Alexander P ReinerDepartment of Epidemiology, University of Washington, Seattle, Washington.
Aaron R FolsomDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota.
University of Minnesota · USJackson Memorial Hospital · USUniversity of Vermont · USUniversity of Washington · USBoston University · USBroad Institute · USGroup Health Cooperative · USMassachusetts Institute of Technology · USNational Institutes of Health · USNorthwestern University · USRoyal North Shore Hospital · AUUniversity of North Carolina at Chapel Hill · USUniversity of Pennsylvania · USUniversity of Virginia · US

Funding

VARIABILITY, STABILITY & SMOOTHNESS OF WALKINGP30AG024827 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Caterina Rosano · 2004 to 2026
$28.6M
Epidemiology of Venous Thrombosis & Pulmonary EmbolismR01HL059367 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI TANG, WEIHONG · 1998 to 2024
$11.8M
Genomic Epidemiology of Cardiovascular DiseaseZIAHL006002 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI O'DONNELL, CHRISTOPHER · 2009 to 2015
$8.0M
CHS Events Follow-up StudyR01HL080295 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M · 2009 to 2014
$6.3M
CHS Events Follow-up StudyU01HL080295 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M · 2005 to 2008
$4.6M
Predictors of Alheimers Disease in Mild Cognitive ImpairmentR01AG020098 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LOPEZ, OSCAR L. · 2002 to 2011
$3.7M
Gene Expression for Functional Genomics in Human PopulationsZIAHL006175 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI O'DONNELL, CHRISTOPHER · 2013 to 2015
$2.2M
Cigarette Smoke and Susceptibility to Influenza InfectionR01HL095163 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JASPERS, ILONA, NOAH, TERRY L · 2009 to 2013
$2.0M
Functional Genetic Variation Underlying Cardiovascular Genomic EpidemiologyZIAHL006173 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI O'DONNELL, CHRISTOPHER · 2013 to 2015
$2.0M
Subcortical Hyperintensities in Sleep Apnea Syndrome.R01HL075366 · NHLBI · NATIONAL JEWISH HEALTH · PI ALOIA, MARK S. · 2004 to 2007
$1.5M
Adjunctive Use of Apyrase to Fibrinolytic TherapyR44HL095169 · NHLBI · APT THERAPEUTICS, INC. · PI CHEN, RIDONG · 2012 to 2013
$1.3M
GENE THERAPY OF DIABETIC PENILE ENDOTHELIAL DYSFUNCTIONR01DK055017 · NIDDK · UNIVERSITY OF WASHINGTON · PI WESSELLS, HUNTER · 2000 to 2004
$1.2M
NHLBI NIH HHS HHSN268200900041CNHLBI NIH HHS HHSN268201300025CNHLBI NIH HHS HHSN268201300026CNHLBI NIH HHS HHSN268201300027CNHLBI NIH HHS HHSN268201300028CNHLBI NIH HHS HHSN268201300029CNHLBI NIH HHS N01 HC015103NHLBI NIH HHS N01 HC025195NHLBI NIH HHS N01 HC035129NHLBI NIH HHS N01 HC055015NHLBI NIH HHS N01 HC055016NHLBI NIH HHS N01 HC055018NHLBI NIH HHS N01 HC055019NHLBI NIH HHS N01 HC055020NHLBI NIH HHS N01 HC055021NHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC065226NHLBI NIH HHS N01 HC075150NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085084NHLBI NIH HHS N01 HC085085NHLBI NIH HHS N01 HC085086NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS R01 HL059367NHLBI NIH HHS R01 HL075366NHLBI NIH HHS R01 HL080295NHLBI NIH HHS R01 HL095603NHLBI NIH HHS R01-HL095603NHLBI NIH HHS R01-HL59367NHLBI NIH HHS U01 HL080295NIA NIH HHS P30 AG024827NIA NIH HHS R01 AG015928NIA NIH HHS R01 AG020098NIA NIH HHS R01 AG027058NIA NIH HHS R01 AG032136NIA NIH HHS R56 AG020098NIDDK NIH HHS R01 DK055017
6 · The paper itself

Abstract

Coagulation factor VIII and von Willebrand factor (VWF) are key proteins in procoagulant activation. Higher FVIII coagulant activity (FVIII :C) and VWF antigen (VWF :Ag) are risk factors for cardiovascular disease and venous thromboembolism. Beyond associations with ABO blood group, genetic determinants of FVIII and VWF are not well understood, especially in non European-American populations. We performed a genetic association study of FVIII :C and VWF:Ag that assessed 50,000 gene-centric single nucleotide polymorphisms (SNPs) in 18,556 European Americans (EAs) and 5,047 African Americans (AAs) from five population-based cohorts. Previously unreported associations for FVIII :C were identified in both AAs and EAs with KNG1 (most significantly associated SNP rs710446, Ile581Thr, Ile581Thr, P = 5.10 × 10(-7) in EAs and P = 3.88 × 10(-3) in AAs) and VWF rs7962217 (Gly2705Arg,P = 6.30 × 10(-9) in EAs and P = 2.98 × 10(-2) in AAs. Significant associations for FVIII :C were also observed with F8/TMLHE region SNP rs12557310 in EAs (P = 8.02 × 10(-10) ), with VWF rs1800380 in AAs (P = 5.62 × 10(-11) ), and with MAT1A rs2236568 in AAs (P51.69 × 10(-6) ). We replicated previously reported associations of FVIII :C and VWF :Ag with the ABO blood group, VWF rs1063856(Thr789Ala), rs216321 (Ala852Gln), and VWF rs2229446 (Arg2185Gln). Findings from this study expand our understanding of genetic influences for FVIII :C and VWF :Ag in both EAs and AAs.

Indexed as

Factor VIIIPolymorphism, Single Nucleotidevon Willebrand FactorAdultAgedBlack or African AmericanFemaleGenetic LociGenome-Wide Association StudyHumansMaleMethionine AdenosyltransferaseMiddle AgedVenous ThromboembolismWhite PeopleF8 protein, humanFactor VIIIMAT1A protein, humanMethionine Adenosyltransferasevon Willebrand Factor

Identifiers

PMID25779970
PMCPMC4747096
OpenAlexW2119695121

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.