ArticleClinical cancer research : an official journal of the American Association for Cancer Research2015
PLEKHA5: A Key to Unlock the Blood-Brain Barrier?
Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- Cell type-specific potential pathogenic genes and functional pathways in Alzheimer's Disease.BMC neurology · 2021Article
- PLEKHA5 regulates the survival and peritoneal dissemination of diffuse-type gastric carcinoma cells with Met gene amplification.Oncogenesis · 2021Article
- Epigenetics Is Implicated in the Basis of Gender Incongruence: An Epigenome-Wide Association Analysis.Frontiers in neuroscience · 2021Article
- Deciphering mechanisms of brain metastasis in melanoma - the gist of the matter.Molecular cancer · 2018Review
- Distinctive epigenomes characterize glioma stem cells and their response to differentiation cues.Genome biology · 2018Article
- Genome-wide profiling of the PIWI-interacting RNA-mRNA regulatory networks in epithelial ovarian cancers.PloS one · 2018Article
- Drug delivery to melanoma brain metastases: Can current challenges lead to new opportunities?Pharmacological research · 2017Article
- Challenges in the delivery of therapies to melanoma brain metastases.Current pharmacology reports · 2016Article
- Mcl-1 downregulation leads to the heightened sensitivity exhibited by BCR-ABL positive ALL to induction of energy and ER-stress.Leukemia research · 2015Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Brain metastases represent a devastating complication of melanoma. Our understanding of the mechanisms driving metastasis to the brain is limited. PLEKHA5 functions as a regulator of brain metastasis in melanoma, and further investigation is warranted to explore the use of PLEKHA5 as a potential therapeutic target.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.