ArticleBulletin of mathematical biology2015
A Mathematical Framework for Understanding Four-Dimensional Heterogeneous Differentiation of CD4+ T Cells.
Article in Bulletin of mathematical biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Emergent dynamics of cellular decision making in multi-node mutually repressive regulatory networks.Journal of the Royal Society, Interface · 2025Article
- Multistability and predominant hybrid phenotypes in a four node mutually repressive network of Th1/Th2/Th17/Treg differentiation.NPJ systems biology and applications · 2024Article
- Early Detection of Daylengths with a Feedforward Circuit Coregulated by Circadian and Diurnal Cycles.Biophysical journal · 2020Article
- Searching for the Mechanisms of Mammalian Cellular Aging Through Underlying Gene Regulatory Networks.Frontiers in genetics · 2020Article
- A mathematical model for understanding synergistic regulations and paradoxical feedbacks in the shoot apical meristem.Computational and structural biotechnology journal · 2020Article
- An enriched network motif family regulates multistep cell fate transitions with restricted reversibility.PLoS computational biology · 2019Article
- Integrative Transcriptomic Analysis Reveals a Multiphasic Epithelial-Mesenchymal Spectrum in Cancer and Non-tumorigenic Cells.Frontiers in oncology · 2019Article
- Combinatorial perturbation analysis reveals divergent regulations of mesenchymal genes during epithelial-to-mesenchymal transition.NPJ systems biology and applications · 2019Article
- Exploring intermediate cell states through the lens of single cells.Current opinion in systems biology · 2018Article
- Controlling Stochasticity in Epithelial-Mesenchymal Transition Through Multiple Intermediate Cellular States.Discrete and continuous dynamical systems. Series B · 2016Article
- Realization of tristability in a multiplicatively coupled dual-loop genetic network.Scientific reports · 2016Article
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3 authors.
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Abstract
At least four distinct lineages of CD4+ T cells play diverse roles in the immune system. Both in vivo and in vitro, naïve CD4+ T cells often differentiate into a variety of cellular phenotypes. Previously, we developed a mathematical framework to study heterogeneous differentiation of two lineages governed by a mutual-inhibition motif. To understand heterogeneous differentiation of CD4+ T cells involving more than two lineages, we present here a mathematical framework for the analysis of multiple stable steady states in dynamical systems with multiple state variables interacting through multiple mutual-inhibition loops. A mathematical model for CD4+ T cells based on this framework can reproduce known properties of heterogeneous differentiation involving multiple lineages of this cell differentiation system, such as heterogeneous differentiation of TH1-TH2, TH1-TH17 and iTReg-TH17 under single or mixed types of differentiation stimuli. The model shows that high concentrations of differentiation stimuli favor the formation of phenotypes with co-expression of lineage-specific master regulators.
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