Evidence map›Paper›PMID 25779719›Full record

ArticleArthritis care & research2016

Role of Sleep Disturbance, Depression, Obesity, and Physical Inactivity in Fatigue in Rheumatoid Arthritis.

Patricia Katz, Mary Margaretten, Laura Trupin, Gabriela Schmajuk, Jinoos Yazdany, Edward Yelin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arthritis care & research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 4 pooled it
8.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 4 syntheses or guidelines pooled it, 113 citations in OpenAlex.

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  4. Sedentary Behavior and Sleep Problems: a Systematic Review and Meta-Analysis.International journal of behavioral medicine · 2017
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  7. Factors Associated With Ambulatory Activity in De Novo Parkinson Disease.Journal of neurologic physical therapy : JNPT · 2017
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Patricia KatzUniversity of California, San Francisco.
Mary MargarettenUniversity of California, San Francisco.
Laura TrupinUniversity of California, San Francisco.
Gabriela SchmajukUniversity of California, San Francisco.
Jinoos YazdanyUniversity of California, San Francisco.
Edward YelinUniversity of California, San Francisco.
University of California, San Francisco · US

Funding

The Interplay of Sociodemographic and Genetic Factors in SLE Health DisparitiesP60AR053308 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CRISWELL, LINDSEY ANN · 2006 to 2016
$11.8M
A rational approach to liver toxicity monitoring in methotrexate usersK23AR063770 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SCHMAJUK, GABRIELA · 2013 to 2017
$670k
NIAMS NIH HHS K23 AR063770NIAMS NIH HHS P60 AR053308
6 · The paper itself

Abstract

objectiveFatigue is a major concern for individuals with rheumatoid arthritis (RA). However, in order to treat fatigue adequately, its sources need to be identified.

methodsData were collected during a single home visit (number of participants = 158). All participants had physician-diagnosed RA. Assessments of self-reported sleep quality, depression, physical activity, RA disease activity, muscle strength, functional limitations, and body composition were made. Information on demographics, medications, and smoking was collected. The Fatigue Severity Inventory (FSI; measuring average fatigue over the past 7 days) was used as the primary outcome. Analyses were first conducted to evaluate bivariate relationships with fatigue. Correlations among risk factors were examined. Multivariate analyses identified independent predictors of fatigue.

resultsThe mean ± SD age was 59 ± 11 years, the mean ± SD disease duration was 21 ± 13 years, and 85% of subjects were female. The mean ± SD FSI rating was 3.8 ± 2.0 (range 0-10). In multivariate analyses, self-reported disease activity, poor sleep, depression, and obesity were independently associated with fatigue. Physical inactivity was correlated with poor sleep, depression, and obesity. Mediation analyses indicated that physical inactivity had an indirect association with fatigue, mediated by poor sleep, depression, and obesity.

conclusionThis cross-sectional study suggests that fatigue may not be solely a result of RA disease activity, but may result from a constellation of factors that includes RA disease activity or pain, but also includes inactivity, depression, obesity, and poor sleep. The results suggest new avenues for interventions to improve fatigue in individuals with RA, such as increasing physical activity or addressing depression or obesity.

Indexed as

Motor ActivitySedentary BehaviorSleepAgedArthritis, RheumatoidCross-Sectional StudiesDepressionFatigueFemaleHumansLinear ModelsMaleMiddle AgedMultivariate AnalysisObesityRisk Factors

Identifiers

PMID25779719
PMCPMC6083443
OpenAlexW2253473202

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.