ArticleScientific reports2015
Collisions of deformable cells lead to collective migration.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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Who cites it
59 citing papers in PubMed, 170 citations in OpenAlex.
- Phase-field modeling of border cell cluster migration in Drosophila.PLoS computational biology · 2026Article
- Physical models of embryonic epithelial healing.PLoS computational biology · 2026Review
- Single-cell chiral symmetry breaking under confinement.bioRxiv : the preprint server for biology · 2026Article
- Partial fluidization theory of collective cell migration.Communications physics · 2026Article
- Durotaxis and extracellular matrix degradation promote the clustering of cancer cells.iScience · 2025Article
- Geometrical constraint change determines organized collective migration of follower cells.Scientific reports · 2025Article
- Confinement, Jamming, and Adhesion in Cancer Cells Dissociating from a Collectively Invading Strand.PRX life · 2025Article
- Derivation and simulation of a computational model of active cell populations: How overlap avoidance, deformability, cell-cell junctions and cytoskeletal forces affect alignment.PLoS computational biology · 2024Article
- Cell deformability drives fluid-to-fluid phase transition in active cell monolayers.Science advances · 2024Article
- Three-component contour dynamics model to simulate and analyze amoeboid cell motility in two dimensions.PloS one · 2024Article
- Polarization and motility of one-dimensional multi-cellular trains.Biophysical journal · 2023Article
- Effect of Porous Substrate Topographies on Cell Dynamics: A Computational Study.ACS biomaterials science & engineering · 2023Article
- Spontaneous motion of a passive fluid droplet in an active microchannel.Soft matter · 2023Article
- Migration and division in cell monolayers on substrates with topological defects.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Molecular-scale substrate anisotropy, crowding and division drive collective behaviours in cell monolayers.Journal of the Royal Society, Interface · 2023Article
- Engineering tools for quantifying and manipulating forces in epithelia.Biophysics reviews · 2023Review
- Computational modeling and simulation of epithelial wound closure.Scientific reports · 2023Article
- The crucial role of adhesion in the transmigration of active droplets through interstitial orifices.Nature communications · 2023Article
- MorphoSim: an efficient and scalable phase-field framework for accurately simulating multicellular morphologies.NPJ systems biology and applications · 2023Article
- Interacting active surfaces: A model for three-dimensional cell aggregates.PLoS computational biology · 2022Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Collective migration of eukaryotic cells plays a fundamental role in tissue growth, wound healing and immune response. The motion, arising spontaneously or in response to chemical and mechanical stimuli, is also important for understanding life-threatening pathologies, such as cancer and metastasis formation. We present a phase-field model to describe the movement of many self-organized, interacting cells. The model takes into account the main mechanisms of cell motility - acto-myosin dynamics, as well as substrate-mediated and cell-cell adhesion. It predicts that collective cell migration emerges spontaneously as a result of inelastic collisions between neighboring cells: collisions lead to a mutual alignment of the cell velocities and to the formation of coherently-moving multi-cellular clusters. Small cell-to-cell adhesion, in turn, reduces the propensity for large-scale collective migration, while higher adhesion leads to the formation of moving bands. Our study provides valuable insight into biological processes associated with collective cell motility.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.