Evidence map›Paper›PMID 25779584›Full record

ArticleAntimicrobial agents and chemotherapy2015

Evolution and single-nucleotide polymorphisms in methicillin-resistant Staphylococcus aureus strains with reduced susceptibility to vancomycin and daptomycin, based on determination of the complete genome.

Tetsuo Yamaguchi, Shingo Suzuki, Sakiko Okamura, Yuri Miura, Ayaka Tsukimori, Itaru Nakamura, Norihiko Ito, Anri Masuya, Takashi Shiina, Tetsuya Matsumoto

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 18 citations in OpenAlex.

  1. Molecular Basis of Non-β-Lactam Antibiotics Resistance inAntibiotics (Basel, Switzerland) · 2022
    Review
  2. Article
  3. ISFrontiers in microbiology · 2019
    Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Tetsuo YamaguchiDepartment of Microbiology, Tokyo Medical University, Tokyo, Japan Department of Infection Control, Tokyo Medical University Hospital, Tokyo, Japan tetsuo.yamaguchi@med.toho-u.ac.jp.
Shingo SuzukiDepartment of Molecular Life Science, Tokai University School of Medicine, Kanagawa, Japan.
Sakiko OkamuraDepartment of Medical Treatment for Health Scientific Research, Bunkyo Gakuin University Graduate School, Tokyo, Japan.
Yuri MiuraDepartment of Microbiology Laboratory, Tokyo Medical University Hospital, Tokyo, Japan.
Ayaka TsukimoriDepartment of Microbiology, Tokyo Medical University, Tokyo, Japan Department of Infection Control, Tokyo Medical University Hospital, Tokyo, Japan.
Itaru NakamuraDepartment of Infection Control, Tokyo Medical University Hospital, Tokyo, Japan.
Norihiko ItoCenter for Biological Resources and Informatics, Dainichiseika-Donated Chair of Research Division for Innovative Biomaterials, Tokyo Institute of Technology, Tokyo, Japan Department of Ophthalmology, Tokyo Medical University Hospital, Tokyo, Japan.
Anri MasuyaDepartment of Molecular Life Science, Tokai University School of Medicine, Kanagawa, Japan.
Takashi ShiinaDepartment of Molecular Life Science, Tokai University School of Medicine, Kanagawa, Japan.
Tetsuya MatsumotoDepartment of Microbiology, Tokyo Medical University, Tokyo, Japan Department of Infection Control, Tokyo Medical University Hospital, Tokyo, Japan.
Tokai University · JPTokyo Medical University Hospital · JPTokyo Medical University · JPBunkyo Gakuin University · JPDainichiseika (Japan) · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We obtained a series of methicillin-resistant Staphylococcus aureus isolates, including both daptomycin-susceptible strain TD1 and daptomycin-resistant strain TD4, from a patient. We determined the complete genome sequences of TD1 and TD4 using next-generation sequencing, and only four single-nucleotide polymorphisms (SNPs) were identified, one each in capB (E58K), rpoB (H481Y), lytN (I16V), and mprF (V351E). We determined that these four SNPs were sufficient to cause the strains to develop daptomycin, vancomycin, and rifampin resistance.

Indexed as

Biological EvolutionAnti-Bacterial AgentsDaptomycinGene Expression Regulation, BacterialMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsMolecular Sequence DataPolymorphism, Single NucleotideVancomycinAnti-Bacterial AgentsDaptomycinVancomycin

Identifiers

PMID25779584
PMCPMC4432144
OpenAlexW1510127541

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.