ArticleAntimicrobial agents and chemotherapy2015
Results of a multinational study suggest the need for rapid diagnosis and early antiviral treatment at the onset of herpetic meningoencephalitis.
Open access · bronzeAbstract readMulticenter Study
In one paragraph
Article in Antimicrobial agents and chemotherapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.
- Unveiling the clinical spectrum of herpes simplex virus CNS infections in adults: a systematic review.Systematic reviews · 2025Pooled it
- Development of a risk score to predict encephalitis by Herpes Simplex Virus and Varicella Zoster Virus.Journal of neurovirology · 2026Observational
- Viral Reactivation in Immunocompetent Critically Ill Patients.Microorganisms · 2026Review
- Article
- Camptothecin, a topoisomerase I inhibitor, impedes productive herpes simplex virus type 1 infection.Journal of virology · 2025Article
- Encephalitis: Predictive Role of Clinical and Diagnostic Data on Outcome-A Monocentric Study.Life (Basel, Switzerland) · 2025Article
- Is intravenous aciclovir overused in possible viral encephalitis? a retrospective review.Journal of neurology · 2025Article
- Herpes simplex encephalitis in France: incidence, 6-month rehospitalizations and mortality.Infection · 2024Article
- Acute hemorrhagic leukoencephalopathy: a case report and literature review.Annals of medicine and surgery (2012) · 2024Article
- Clinical characteristics and outcomes of patients with Herpes Simplex Encephalitis in Vietnam: a retrospective study.BMC infectious diseases · 2024Article
- Can we forecast poor outcome in herpes simplex and varicella zoster encephalitis? A narrative review.Frontiers in neurology · 2023Review
- Biofire FilmArray Meningitis/Encephalitis panel for the aetiological diagnosis of central nervous system infections: A systematic review and diagnostic test accuracy meta-analysis.EClinicalMedicine · 2022Article
- Characteristics and outcome of varicella-zoster virus central nervous system infections in adults.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2021Observational
- Assessment of Magnetic Resonance Imaging Changes and Functional Outcomes Among Adults With Severe Herpes Simplex Encephalitis.JAMA network open · 2021Article
- Prevalence and clinical manifestations of herpes simplex virus infection among suspected patients of herpes simplex encephalitis in Shiraz, Iran.Virusdisease · 2021Article
- Compliance with international guidelines in adults with encephalitis.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2020Article
- Immunomodulatory Strategies in Herpes Simplex Virus Encephalitis.Clinical microbiology reviews · 2020Review
- Long-Term Survival, Morbidity, Social Functioning and Risk of Disability in Patients with a Herpes Simplex Virus Type 1 or Type 2 Central Nervous System Infection, Denmark, 2000-2016.Clinical epidemiology · 2020Article
- The Use of Adjunctive Steroids in Central Nervous Infections.Frontiers in cellular and infection microbiology · 2020Review
- Herpes Simplex Virus Encephalitis: Patterns of Epidemiology and Outcomes of Patients Admitted to the Intensive Care Unit in Texas, 2008 - 2016.Journal of clinical medicine research · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
51 authors at 20 institutions in 11 countries.
Hakan ErdemGATA Haydarpasa Training Hospital, Department of Infectious Diseases and Clinical Microbiology, Istanbul, Turkey hakanerdem1969@yahoo.com.
Yasemin CagDr. Lutfi Kirdar Training and Research Hospital, Department of Infectious Diseases and Clinical Microbiology, Istanbul, Turkey.
Derya Ozturk-EnginHaydarpaşa Numune Training and Research Hospital, Department of Infectious Diseases and Clinical Microbiology, Istanbul, Turkey.
Sylviane DefresInstitute of Infection & Global Health, University of Liverpool, Liverpool, Merseyside, United Kingdom Tropical Infectious Diseases Unit at Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool, United Kingdom.
Selcuk KayaKaradeniz Technical University School of Medicine, Department of Infectious Diseases and Clinical Microbiology, Trabzon, Turkey.
Lykke LarsenOdense University Hospital, Department of Infectious Diseases Q, Odense, Denmark.
Mario PoljakInstitute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
Bruno BarsicDr. Fran Mihaljevic University Hospital for Infectious Diseases, Department of Infectious Diseases, University of Zagreb School of Medicine, Zagreb, Croatia.
Xavier ArgemiNouvel Hôpital Civil, Department of Infectious Diseases, Strasbourg, France.
Signe Maj SørensenAalborg University Hospital, Department of Infectious Diseases, Aalborg, Denmark.
Anne Lisbeth BohrCopenhagen University Hospital, Institute of Inflammation Research, Department of Infectious Diseases and Rheumatology, Rigshospitalet, Copenhagen, Denmark.
Pierre TattevinInfectious Diseases and Intensive Care Unit, Pontchaillou University Hospital, Rennes, France.
Jesper Damsgaard GunstAarhus University Hospital, Department of Infectious Diseases, Aarhus, Denmark.
Lenka BaštákováFaculty Hospital Brno, Department of Infectious Diseases and Masaryk University Faculty of Medicine, Brno, Czech Republic.
Matjaž JerebUniversity Medical Centre, Department of Infectious Diseases, Ljubljana, Slovenia.
Isik Somuncu JohansenOdense University Hospital, Department of Infectious Diseases Q, Odense, Denmark.
Oguz KarabaySakarya University School of Medicine, Department of Infectious Diseases and Clinical Microbiology, Sakarya, Turkey.
Abdullah Umut PekokPrivate Erzurum Sifa Hospital, Department of Infectious Diseases and Clinical Microbiology, Erzurum, Turkey.
Oguz Resat SipahiEge University School of Medicine, Department of Infectious Diseases and Clinical Microbiology, Izmir, Turkey.
Mahtab ChehriHvidovre Hospital, Department of Infectious Diseases, Copenhagen, Denmark.
Guillaume BeraudPoitiers University Hospital, Department of Infectious Diseases, Poitiers, France.
Ghaydaa ShehataAssiut University Hospital, Department of Neurology and Psychiatry, Assiut, Egypt.
Rosa Fontana Del VecchioUniversity of Catania, Section of Infectious Diseases, Department of Clinical and Molecular Biomedicine, Catania, Italy.
Mauro MarescaUniversity of Catania, Section of Infectious Diseases, Department of Clinical and Molecular Biomedicine, Catania, Italy.
Hasan KarsenHarran University, School of Medicine, Department of Infectious Diseases and Clinical Microbiology, Sanliurfa, Turkey.
Gonul SengozHaseki Training and Research Hospital, Department of Infectious Diseases and Clinical Microbiology, Istanbul, Turkey.
Mustafa SunbulOndokuz Mayis University School of Medicine, Department of Infectious Diseases and Clinical Microbiology, Samsun, Turkey.
Gulden YilmazAnkara University School of Medicine, Department of Infectious Diseases and Clinical Microbiology, Ankara, Turkey.
Hava YilmazOndokuz Mayis University School of Medicine, Department of Infectious Diseases and Clinical Microbiology, Samsun, Turkey.
Ahmad Sharif-YakanAmerican University of Beirut Medical Center, Beirut, Lebanon.
Souha Shararah KanjAmerican University of Beirut Medical Center, Beirut, Lebanon.
Emine ParlakAtaturk University School of Medicine, Department of Infectious Diseases and Clinical Microbiology, Erzurum, Turkey.
Filiz PehlivanogluHaseki Training and Research Hospital, Department of Infectious Diseases and Clinical Microbiology, Istanbul, Turkey.
Fatime KorkmazKonya Training and Research Hospital, Department of Infectious Diseases and Clinical Microbiology, Konya, Turkey.
Suheyla KomurCukurova University School of Medicine, Department of Infectious Diseases and Clinical Microbiology, Adana, Turkey.
Sukran KoseTepecik Training and Research Hospital, Department of Infectious Diseases and Clinical Microbiology, Izmir, Turkey.
Mehmet UlugPrivate Umit Hospital, Department of Infectious Diseases and Clinical Microbiology, Eskisehir, Turkey.
Sibel BolukcuHaydarpaşa Numune Training and Research Hospital, Department of Infectious Diseases and Clinical Microbiology, Istanbul, Turkey.
Seher Ayten Coskunerİzmir Bozyaka Training and Research Hospital, Department of Infectious Diseases and Clinical Microbiology, Izmir, Turkey.
Nevin InceDüzce University School of Medicine, Department of Infectious Diseases and Clinical Microbiology, Konuralp, Düzce, Turkey.
Yasemin AkkoyunluBezmi Alem Vakif University, School of Medicine, Department of Infectious Diseases and Clinical Microbiology, Istanbul, Turkey.
Gulistan HalacBezmi Alem Vakif University, School of Medicine, Department of Neurology, Istanbul, Turkey.
Elif Sahin-HorasanMersin University School of Medicine, Department of Infectious Diseases and Clinical Microbiology, Mersin, Turkey.
Hulya TireliHaydarpaşa Numune Training and Research Hospital, Department of Neurology, Istanbul, Turkey.
Gamze KilicogluHaydarpaşa Numune Training and Research Hospital, Department of Radiology, Istanbul, Turkey.
Akram Al-MahdawiDepartment of Neurology, Baghdad Teaching Hospital, Baghdad, Iraq.
Salih Atakan NemliKatip Celebi University School of Medicine, Department of Infectious Diseases and Clinical Microbiology, Izmir, Turkey.
Asuman InanHaydarpaşa Numune Training and Research Hospital, Department of Infectious Diseases and Clinical Microbiology, Istanbul, Turkey.
Seniha SenbayrakHaydarpaşa Numune Training and Research Hospital, Department of Infectious Diseases and Clinical Microbiology, Istanbul, Turkey.
Jean Paul StahlJoseph Fourier University and University Hospital of Grenoble, Department of Infectious Diseases, Grenoble, France.
Haluk VahabogluMedeniyet University, Goztepe Training and Research Hospital, Department of Infectious Diseases and Clinical Microbiology, Istanbul, Turkey.
Haydarpaşa Numune Eğitim ve Araştırma Hastanesi · TRAmerican University of Beirut Medical Center · LBBezmiâlem Vakıf Üniversitesi · TRHaseki Eğitim ve Araştırma Hastanesi · TROdense University Hospital · DKOndokuz Mayıs University · TRUniversity of Catania · ITAalborg University Hospital · DKAarhus University Hospital · DKAnkara University · TRAssiut University · EGAtatürk University · TRBaghdad Medical City · IQCukurova University · TRDr Lütfi Kırdar Kartal Eğitim ve Araştırma Hastanesi · TRDüzce Üniversitesi · TREge University · TRErzurum Regional Training and Research Hospital · TREskişehir City Hospital · TRGATA Haydarpaşa Eğitim Hastanesi · TR
Funding
No grant is acknowledged in the PubMed record.
Abstract
Data in the literature regarding the factors that predict unfavorable outcomes in adult herpetic meningoencephalitis (HME) cases are scarce. We conducted a multicenter study in order to provide insights into the predictors of HME outcomes, with special emphasis on the use and timing of antiviral treatment. Samples from 501 patients with molecular confirmation from cerebrospinal fluid were included from 35 referral centers in 10 countries. Four hundred thirty-eight patients were found to be eligible for the analysis. Overall, 232 (52.9%) patients experienced unfavorable outcomes, 44 died, and 188 survived, with sequelae. Age (odds ratio [OR], 1.04; 95% confidence interval [CI], 1.02 to 1.05), Glasgow Coma Scale score (OR, 0.84; 95% CI, 0.77 to 0.93), and symptomatic periods of 2 to 7 days (OR, 1.80; 95% CI, 1.16 to 2.79) and >7 days (OR, 3.75; 95% CI, 1.72 to 8.15) until the commencement of treatment predicted unfavorable outcomes. The outcome in HME patients is related to a combination of therapeutic and host factors. This study suggests that rapid diagnosis and early administration of antiviral treatment in HME patients are keys to a favorable outcome.
Indexed as
AdultAntiviral AgentsConfidence IntervalsEncephalitis, Herpes SimplexFemaleHumansMaleMiddle AgedRetrospective StudiesTreatment OutcomeAntiviral Agents
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.