ArticleAntimicrobial agents and chemotherapy2015
Ceftriaxone-resistant Salmonella enterica serotype typhimurium sequence type 313 from Kenyan patients is associated with the blaCTX-M-15 gene on a novel IncHI2 plasmid.
Article in Antimicrobial agents and chemotherapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
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Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- Prevalence and outcome of bloodstream infections due to third-generation cephalosporin-resistant Enterobacteriaceae in sub-Saharan Africa: a systematic review.The Journal of antimicrobial chemotherapy · 2020Pooled it
- Detection and Characterization of Salmonella enterica Serotypes by Simple PCR Technologies.Methods in molecular biology (Clifton, N.J.) · 2027Article
- The Microbial Trojan Horse and Antimicrobial Resistance: Acanthamoeba as an Environmental Reservoir for Multidrug Resistant Bacteria.Environmental microbiology · 2025Article
- Phenotypic markers misclassify isolates of Salmonella Typhimurium as S. Typhi, but were correctly identified by whole genome sequencing during a septicemia study in western Kenya.PLOS global public health · 2025Article
- Co-selection for antibiotic resistance by environmental contaminants.npj antimicrobials and resistance · 2024Review
- Association of Sickle Cell Disease, Malaria and HIV in Multi Drug Resistant Invasive Non-typhoidalEast Africa science · 2024Article
- A genomic appraisal of invasive Salmonella Typhimurium and associated antibiotic resistance in sub-Saharan Africa.Nature communications · 2023Review
- A global genomic analysis of Salmonella Concord reveals lineages with high antimicrobial resistance in Ethiopia.Nature communications · 2023Review
- NontyphoidalOpen forum infectious diseases · 2023Article
- Prevalence and genomic characterization ofFrontiers in microbiology · 2023Article
- Whole genome sequence analysis of ESBL-producingMicrobial genomics · 2022Article
- Antimicrobial Resistance Rates and Surveillance in Sub-Saharan Africa: Where Are We Now?Infection and drug resistance · 2022Review
- The genomic epidemiology of multi-drug resistant invasive non-typhoidalBMJ global health · 2021Article
- Detection of multidrug-resistantVeterinary world · 2021Article
- Comparative genomic and phenotypic characterization of invasive non-typhoidal Salmonella isolates from Siaya, Kenya.PLoS neglected tropical diseases · 2021Article
- Epidemiology and Characterization of CTX-M-55-Type Extended-Spectrum β-Lactamase-ProducingMicroorganisms · 2021Article
- Pathogenic signature of invasive non-typhoidalHuman vaccines & immunotherapeutics · 2020Review
- Tracking Antimicrobial Resistance Determinants in Diarrheal Pathogens: A Cross-Institutional Pilot Study.International journal of molecular sciences · 2020Article
- Genetic variation in the MacAB-TolC efflux pump influences pathogenesis of invasive Salmonella isolates from Africa.PLoS pathogens · 2020Article
- Research on Invasive Nontyphoidal Salmonella Disease and Developments Towards Better Understanding of Epidemiology, Management, and Control Strategies.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Article
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Multidrug-resistant bacteria pose a major challenge to the clinical management of infections in resource-poor settings. Although nontyphoidal Salmonella (NTS) bacteria cause predominantly enteric self-limiting illness in developed countries, NTS is responsible for a huge burden of life-threatening bloodstream infections in sub-Saharan Africa. Here, we characterized nine S. Typhimurium isolates from an outbreak involving patients who initially failed to respond to ceftriaxone treatment at a referral hospital in Kenya. These Salmonella enterica serotype Typhimurium isolates were resistant to ampicillin, chloramphenicol, cefuroxime, ceftriaxone, aztreonam, cefepime, sulfamethoxazole-trimethoprim, and cefpodoxime. Resistance to β-lactams, including to ceftriaxone, was associated with carriage of a combination of blaCTX-M-15, blaOXA-1, and blaTEM-1 genes. The genes encoding resistance to heavy-metal ions were borne on the novel IncHI2 plasmid pKST313, which also carried a pair of class 1 integrons. All nine isolates formed a single clade within S. Typhimurium ST313, the major clone of an ongoing invasive NTS epidemic in the region. This emerging ceftriaxone-resistant clone may pose a major challenge in the management of invasive NTS in sub-Saharan Africa.
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