ArticleScientific reports2015
A magnetic anti-cancer compound for magnet-guided delivery and magnetic resonance imaging.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Article
- EP4-induced mitochondrial localization and cell migration mediated by CALML6 in human oral squamous cell carcinoma.Communications biology · 2024Article
- Flexible and sewable electrode based on Ni-Co@PANI-salphen composite-coated on textiles for wearable supercapacitor.Scientific reports · 2023Article
- Magnetic Temperature-Sensitive Solid-Lipid Particles for Targeting and Killing Tumor Cells.Frontiers in chemistry · 2020Article
- Controlled Drug Delivery Systems for Oral Cancer Treatment-Current Status and Future Perspectives.Pharmaceutics · 2019Review
- Tuning the surface coating of IONs toward efficient sonochemical tethering and sustained liberation of topoisomerase II poisons.International journal of nanomedicine · 2019Article
- Simultaneous hyperthermia-chemotherapy effect by arterial injection of Fe(Salen) for femur tumor.Cancer science · 2019Article
- Alternating magnetic field enhances cytotoxicity of Compound C.Cancer science · 2018Article
- Acute Hyperthermia Inhibits TGF-β1-induced Cardiac Fibroblast Activation via Suppression of Akt Signaling.Scientific reports · 2018Article
- Treatment of oral cancer using magnetized paclitaxel.Oncotarget · 2018Article
- Transient receptor potential cation 3 channel regulates melanoma proliferation and migration.The journal of physiological sciences : JPS · 2017Article
- Hyperthermia and chemotherapy using Fe(Salen) nanoparticles might impact glioblastoma treatment.Scientific reports · 2017Article
- miR-663a regulates growth of colon cancer cells, after administration of antimicrobial peptides, by targeting CXCR4-p21 pathway.BMC cancer · 2017Article
- Simultaneous hyperthermia-chemotherapy with controlled drug delivery using single-drug nanoparticles.Scientific reports · 2016Article
- The Human Cathelicidin Antimicrobial Peptide LL-37 and Mimics are Potential Anticancer Drugs.Frontiers in oncology · 2015Review
Corrections and comments
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Authors and funding
22 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Research on controlled drug delivery for cancer chemotherapy has focused mainly on ways to deliver existing anti-cancer drug compounds to specified targets, e.g., by conjugating them with magnetic particles or encapsulating them in micelles. Here, we show that an iron-salen, i.e., μ-oxo N,N'- bis(salicylidene)ethylenediamine iron (Fe(Salen)), but not other metal salen derivatives, intrinsically exhibits both magnetic character and anti-cancer activity. X-Ray crystallographic analysis and first principles calculations based on the measured structure support this. It promoted apoptosis of various cancer cell lines, likely, via production of reactive oxygen species. In mouse leg tumor and tail melanoma models, Fe(Salen) delivery with magnet caused a robust decrease in tumor size, and the accumulation of Fe(Salen) was visualized by magnetic resonance imaging. Fe(Salen) is an anti-cancer compound with magnetic property, which is suitable for drug delivery and imaging. We believe such magnetic anti-cancer drugs have the potential to greatly advance cancer chemotherapy for new theranostics and drug-delivery strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.