Evidence map›Paper›PMID 25779348›Full record

ReviewChimerism2014

Microchimerism in women with recurrent miscarriage.

Hilary S Gammill, Mary D Stephenson, Tessa M Aydelotte, J Lee Nelson

Open access · bronzeAbstract readReview
In one paragraph

Review in Chimerism, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Hilary S Gammilla Clinical Research Division; Fred Hutchinson Cancer Research Center ; Seattle , WA USA.
Mary D Stephensonc Department of Obstetrics and Gynecology ; University of Chicago ; Chicago , IL USA.
Tessa M Aydelottea Clinical Research Division; Fred Hutchinson Cancer Research Center ; Seattle , WA USA.
J Lee Nelsona Clinical Research Division; Fred Hutchinson Cancer Research Center ; Seattle , WA USA.
University of Washington · USFred Hutch Cancer Center · USUniversity of Chicago · US

Funding

WOMEN'S REPRODUCTIVE HEALTH RESEARCH CAREER DEVELOPMENTK12HD001264 · NICHD · UNIVERSITY OF WASHINGTON · PI Barbara Ann Goff · 1998 to 2026
$8.6M
The Maternal Anti-fetal Immune Response & Role of Microchimerism in PreeclamsiaK08HD067221 · NICHD · UNIVERSITY OF WASHINGTON · PI GAMMILL, HILARY SEGLIN · 2012 to 2016
$644k
Transgenerational Microchimerism in Pregnancy LossR21AI072547 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI NELSON, J. LEE · 2007 to 2008
$483k
NIAID NIH HHS AI072547NICHD NIH HHS HD01264NICHD NIH HHS HD067221NICHD NIH HHS K08 HD067221
6 · The paper itself

Abstract

Miscarriage is the most common pregnancy complication, and recurrent miscarriage (3 or more consecutive pregnancy losses) affects 1-5% of couples. Maternal-fetal exchange and the persistence of exchanged material as microchimerism appears to be disrupted in complicated pregnancies. We recently conducted a longitudinal cohort study of microchimerism in women with recurrent miscarriage. Our initial data raise multiple questions that require further investigation. Here, we review our data from this recent study and provide additional information regarding microchimerism in the granulocyte cell layer. This area of investigation offers a unique window into early reproductive events, and future related studies have the potential to identify novel therapeutic approaches and insights into human evolution.

Indexed as

ChimerismAbortion, HabitualFemaleGranulocytesHumansMaternal-Fetal ExchangePregnancymicrochimerismpregnancyrecurrent miscarriagereproduction

Identifiers

PMID25779348
PMCPMC5154341
OpenAlexW2328784120

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.