Evidence map›Paper›PMID 25779095›Full record

ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2015

Weakening of Corticomuscular Signal Coupling During Voluntary Motor Action in Aging.

Mehmed Bugrahan Bayram, Vlodek Siemionow, Guang H Yue

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 4 pooled it
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 4 syntheses or guidelines pooled it, 61 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Mehmed Bugrahan BayramDepartment of Medical Engineering, Acibadem University, Istanbul, Turkey. Human Performance and Engineering Research, Kessler Foundation, West Orange, New Jersey. Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Ohio. bugrahan.bayram@outlook.com.
Vlodek SiemionowDepartment of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Ohio. Department of Physical Medicine and Rehabilitation, Neurological Institute, Cleveland Clinic, Ohio.
Guang H YueHuman Performance and Engineering Research, Kessler Foundation, West Orange, New Jersey. Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Ohio. Department of Physical Medicine and Rehabilitation, Neurological Institute, Cleveland Clinic, Ohio. Department of Physical Medicine and Rehabilitation, Rutgers New Jersey Medical School, The State University of New Jersey, Newark.
Acıbadem University · TRKessler Foundation · US

Funding

MENTAL TRAINING EFFECTS ON VOLUNTARY MUSCLE STRENGTHR01NS035130 · NINDS · CLEVELAND CLINIC LERNER COM-CWRU · PI YUE, GUANG H · 1997 to 2012
$1.7M
NINDS NIH HHS R01 NS035130
6 · The paper itself

Abstract

backgroundAging is associated with muscle weakness and impairment in performing skilled motor tasks. Still, little is known about whether the link or functional coupling or connection between the central and peripheral systems during voluntary motor performance is compromised in the elderly subjects. The purposes of this study were to estimate functional corticomuscular connection (CMC) strength in the elderly subjects by calculating EEG-EMG coherence during voluntary motor performance, determine the relationship between the CMC and voluntary muscle force, and compare these between the old and the young subjects.

methodsMaximal voluntary contraction (MVC) of elbow flexion (EF) and EFs at three submaximal (20%, 50%, and 80% MVC) levels were performed in 28 healthy older (74.96±1.32 years) and 20 young (22.60±0.90 years) individuals, while EEG and EMG from biceps brachii, brachioradialis, and triceps brachii muscles were recorded simultaneously.

resultsCompared with the young, older individuals exhibited significantly weakened CMC at all force levels tested. There was a proportional relationship between the CMC and EF force and high-positive correlation between the CMC and EF strength in both groups.

conclusionsWeakened CMC in aging may be a major factor contributing to age-related muscle weakness, and the linear relationship between the CMC and voluntary muscle force suggests dependence of force output on translation of the descending command to muscle electrical signal.

Indexed as

AgedAgingBrainElectroencephalographyElectromyographyFemaleHumansMaleMuscle, SkeletalMuscle WeaknessBiomarkersBrain agingMotor control

Identifiers

PMID25779095
PMCPMC4573669
OpenAlexW2124273364

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.