ArticleScientific reports2015
Age-dependent association between sex and renal cell carcinoma mortality: a population-based analysis.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 44 citations in OpenAlex.
- Trial
- Integrative analysis of the roles and prognostic value of RNA-binding proteins in papillary renal cell carcinoma.Discover oncology · 2026Article
- The Role of Estrogen Signaling Pathway and Targeted Therapy Exploration in Urological Tumors.International journal of biological sciences · 2026Review
- The correlation between clinical and pathological features of renal cancer patients with survival after surgical intervention.Caspian journal of internal medicine · 2026Article
- The correlation between serum sex hormone levels and clear cell renal cell carcinoma in male patients.Scientific reports · 2025Article
- Clinical and molecular prognostic nomograms for patients with papillary renal cell carcinoma.Discover oncology · 2024Article
- SiRCle (Signature Regulatory Clustering) model integration reveals mechanisms of phenotype regulation in renal cancer.Genome medicine · 2024Article
- Article
- Article
- Global burden, trends, and disparities in kidney cancer attributable to smoking from 1990 to 2021.Frontiers in public health · 2024Article
- Divulging a Pleiotropic Role of Succinate ReceptorCancers · 2022Article
- [Clinicopathological features and prognostic analysis of papillary renal cell carcinoma].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2022Article
- Survival Improvement in Patients with Renal Cell Carcinoma and Disparities between Different Sexes, Races, and Socioeconomic Status: 1977-2016.Journal of oncology · 2022Article
- Sex-specific hormone changes during immunotherapy and its influence on survival in metastatic renal cell carcinoma.Cancer immunology, immunotherapy : CII · 2021Article
- Article
- Development and Validation of a Predictive Model to Evaluate the Risk of Bone Metastasis in Kidney Cancer.Frontiers in oncology · 2021Article
- Growth Rates of Genetically Defined Renal Tumors: Implications for Active Surveillance and Intervention.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2020Article
- Gene Expression and Co-expression Networks Are Strongly Altered Through Stages in Clear Cell Renal Carcinoma.Frontiers in genetics · 2020Article
- Prognostic Role of Prothrombin Time Activity, Prothrombin Time, Albumin/Globulin Ratio, Platelets, Sex, and Fibrinogen in Predicting Recurrence-Free Survival Time of Renal Cancer.Cancer management and research · 2020Article
- Impact of Estrogen on the Relationship Between Obesity and Renal Cell Carcinoma Risk in Women.EBioMedicine · 2018Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Research on sex differences in renal cancer-specific mortality (RCSM), which considered the sex effect to be constant throughout life, has yielded conflicting results. This study hypothesized the sex effect may be modified by age, which is a proxy for hormonal status. Data from the Surveillance, Epidemiology and End Results database (1988-2010) were used to identify 114,539 patients with renal cell carcinoma (RCC). The study cohort was divided into three age groups using cutoffs of 42 and 58 years, which represent the premenopausal and postmenopausal periods. The cumulative incidence function and competing risks analyses were used to examine the effect of covariates on RCSM and other-cause mortality (OCM). In premenopausal period, male sex was a significant predictor of poor RCSM for both localized (adjusted subdistribution hazard ratio [aSHR] = 1.63, P = 0.002) and advanced (aSHR = 1.20, P = 0.041) disease. In postmenopausal period, the sex disparity diminished (aSHR = 1.05, P = 0.16) and reversed (aSHR = 0.95, P = 0.017) in localized and advanced disease, respectively. On the contrary, similar trend was not found for OCM across all age groups. Our results demonstrated the sex effect on RCSM was strongly modified by age. These findings may aid in clinical practice and need further evaluation of underlying biological mechanisms.
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