ArticlePsychiatry research2015
Widespread white matter tract aberrations in youth with familial risk for bipolar disorder.
Article in Psychiatry research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Structural connectivity associated with familial risk for mental illness: A meta-analysis of diffusion tensor imaging studies in relatives of patients with severe mental disorders.Human brain mapping · 2022Pooled it
- White Matter Microstructure in Individuals With and At Risk for Bipolar Disorder: Evidence for an Endophenotype From a Voxel-Based Meta-analysis.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2020Pooled it
- Neuroprotection after a first episode of mania: a randomized controlled maintenance trial comparing the effects of lithium and quetiapine on grey and white matter volume.Translational psychiatry · 2017Trial
- Neuroinflammation and white matter microstructure as mediators of cognitive deficits in offspring of parents with bipolar disorder.Brain communications · 2026Article
- Mapping Structural Neuroimaging Trajectories in Bipolar Disorder: Neurobiological and Clinical Implications.Biological psychiatry · 2025Review
- Association of polygenic risk for bipolar disorder with grey matter structure and white matter integrity in youth.Translational psychiatry · 2023Article
- Differential association of antioxidative defense genes with white matter integrity in youth bipolar disorder.Translational psychiatry · 2022Article
- The inferior frontal gyrus and familial risk for bipolar disorder.Psychoradiology · 2022Review
- Integrity of the uncinate fasciculus is associated with the onset of bipolar disorder: a 6-year followed-up study.Translational psychiatry · 2021Article
- White matter microstructure in youth with and at risk for bipolar disorder.Bipolar disorders · 2020Article
- Diffusion imaging markers of bipolar versus general psychopathology risk in youth at-risk.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Structural dysconnectivity of key cognitive and emotional hubs in young people at high genetic risk for bipolar disorder.Molecular psychiatry · 2018Article
- Longitudinal Diffusion Tensor Imaging Study of Adolescents and Young Adults With Bipolar Disorder.Journal of the American Academy of Child and Adolescent Psychiatry · 2018Article
- White matter volumes in youth offspring of bipolar parents.Journal of affective disorders · 2017Article
- Similar white matter changes in schizophrenia and bipolar disorder: A tract-based spatial statistics study.PloS one · 2017Article
- A comprehensive tractography study of patients with bipolar disorder and their unaffected siblings.Human brain mapping · 2016Article
- Is There a Bipolar Prodrome Among Children and Adolescents?Current psychiatry reports · 2016Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Few studies have examined multiple measures of white matter (WM) differences in youth with familial risk for bipolar disorder (FR-BD). To investigate WM in the FR-BD group, we used three measures of WM structure and two methods of analysis. We used fractional anisotropy (FA), axial diffusivity (AD), and radial diffusivity (RD) to analyze diffusion tensor imaging (DTI) findings in 25 youth with familial risk for bipolar disorder, defined as having both a parent with BD and mood dysregulation, and 16 sex-, age-, and IQ-matched healthy controls. We conducted a whole brain voxelwise analysis using tract based spatial statistics (TBSS). Subsequently, we conducted a complementary atlas-based, region-of-interest analysis using Diffeomap to confirm results seen in TBSS. When TBSS was used, significant widespread between-group differences were found showing increased FA, increased AD, and decreased RD in the FR-BD group in the bilateral uncinate fasciculus, cingulum, cingulate, superior fronto-occipital fasciculus (SFOF), superior longitudinal fasciculus (SLF), inferior longitudinal fasciculus, and corpus callosum. Atlas-based analysis confirmed significant between-group differences, with increased FA and decreased RD in the FR-BD group in the SLF, cingulum, and SFOF. We found significant widespread WM tract aberrations in youth with familial risk for BD using two complementary methods of DTI analysis.
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