Evidence map›Paper›PMID 25778927›Full record

ArticleJournal of pharmaceutical and biomedical analysis2015

Characterization of cyclic peptides containing disulfide bonds.

Mindy Johnson, Mingtao Liu, Elaine Struble, Kanthi Hettiarachchi

Abstract read
In one paragraph

Article in Journal of pharmaceutical and biomedical analysis, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Gold(I) Cationization Promotes Ring Opening in Lysine-Containing Cyclic Peptides.Journal of the American Society for Mass Spectrometry · 2019
    Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mindy JohnsonPharmaceutical Development Section, Biosciences Division, SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025 United States of America.
Mingtao LiuPharmaceutical Development Section, Biosciences Division, SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025 United States of America.
Elaine StrublePharmaceutical Development Section, Biosciences Division, SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025 United States of America.
Kanthi HettiarachchiPharmaceutical Development Section, Biosciences Division, SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025 United States of America. Electronic address: kanthi.hettiarachchi@gmail.com.

Funding

NIDA NIH HHS HHSN271200800049CNIDA NIH HHS HHSN271201300013CPHS HHS HHSN271200800049CPHS HHS HHSN 271201300013C
6 · The paper itself

Abstract

Unlike linear peptides, analysis of cyclic peptides containing disulfide bonds is not straightforward and demands indirect methods to achieve a rigorous proof of structure. Three peptides that belong to this category, p-Cl-Phe-DPDPE, DPDPE, and CTOP, were analyzed and the results are presented in this paper. The great potential of two dimensional NMR and ESI tandem mass spectrometry was harnessed during the course of peptide characterizations. A new RP-HPLC method for the analysis of trifluoroacetic acid is also presented. It is robust, simple, and efficient compared to the currently available methods.

Indexed as

Acetic AcidChromatography, High Pressure LiquidDisulfidesDithiothreitolEnkephalin, D-Penicillamine (2,5)-Indicators and ReagentsMagnetic Resonance SpectroscopyPeptides, CyclicSomatostatinTandem Mass SpectrometryTrifluoroacetic AcidAcetic AcidDisulfidesDithiothreitolEnkephalin, D-Penicillamine (2,5)-Indicators and ReagentsPeptides, Cyclicphenylalanyl-cyclo(cysteinyltyrosyl-tryptophyl-ornithyl-threonyl-penicillamine)threoninamideSomatostatinTrifluoroacetic AcidOpioid peptidesRP-HPLCTandem mass spectrometryTrifluoroacetic acidTwo-dimensional NMR

Identifiers

PMID25778927
PMCPMC4608431

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.