ArticleThe Journal of cell biology2015
PAPC mediates self/non-self-distinction during Snail1-dependent tissue separation.
Article in The Journal of cell biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 30 citations in OpenAlex.
- Article
- Cell cortex regulation by the planar cell polarity protein Prickle1.The Journal of cell biology · 2022Article
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- Retinoic Acid is Required for Normal Morphogenetic Movements During Gastrulation.Frontiers in cell and developmental biology · 2022Article
- Cell-cell contact landscapes inProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Convergent extension in the amphibian, Xenopus laevis.Current topics in developmental biology · 2020Review
- Models of convergent extension during morphogenesis.Wiley interdisciplinary reviews. Developmental biology · 2018Review
- Mechanics of Fluid-Filled Interstitial Gaps. II. Gap Characteristics in Xenopus Embryonic Ectoderm.Biophysical journal · 2017Article
- Sorting at embryonic boundaries requires high heterotypic interfacial tension.Nature communications · 2017Article
- Article
- Mechanics of tissue compaction.Seminars in cell & developmental biology · 2015Review
- Balancing cell behavior at boundaries.The Journal of cell biology · 2015Article
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12 authors at 2 institutions in 2 countries.
Funding
Abstract
Cleft-like boundaries represent a type of cell sorting boundary characterized by the presence of a physical gap between tissues. We studied the cleft-like ectoderm-mesoderm boundary in Xenopus laevis and zebrafish gastrulae. We identified the transcription factor Snail1 as being essential for tissue separation, showed that its expression in the mesoderm depends on noncanonical Wnt signaling, and demonstrated that it enables paraxial protocadherin (PAPC) to promote tissue separation through two novel functions. First, PAPC attenuates planar cell polarity signaling at the ectoderm-mesoderm boundary to lower cell adhesion and facilitate cleft formation. Second, PAPC controls formation of a distinct type of adhesive contact between mesoderm and ectoderm cells that shows properties of a cleft-like boundary at the single-cell level. It consists of short stretches of adherens junction-like contacts inserted between intermediate-sized contacts and large intercellular gaps. These roles of PAPC constitute a self/non-self-recognition mechanism that determines the site of boundary formation at the interface between PAPC-expressing and -nonexpressing cells.
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