ArticleScientific reports2015
Requirement of CHROMOMETHYLASE3 for somatic inheritance of the spontaneous tomato epimutation Colourless non-ripening.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 65 citations in OpenAlex.
- The carotenoids metabolism during tomato fruit ripening: insights into multi-level regulatory network.BMC plant biology · 2026Review
- Article
- Genome-Wide Identification and Analysis of DNA Methyltransferase and Demethylase Gene Families in Sweet Potato and Its Diploid Relative.Plants (Basel, Switzerland) · 2025Article
- Systematic Analysis of DNA Demethylase Gene Families in Foxtail Millet (International journal of molecular sciences · 2024Article
- Epigenetic insights into an epimutantFrontiers in plant science · 2024Review
- DNA cytosine methylation dynamics and functional roles in horticultural crops.Horticulture research · 2023Article
- Proteomic Changes in Response toPlants (Basel, Switzerland) · 2022Article
- Exploitation of epigenetic variation of crop wild relatives for crop improvement and agrobiodiversity preservation.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Review
- Review
- CRISPR/Cas9-targeted mutagenesis ofHorticulture research · 2022Article
- Epigenome plasticity in plants.Nature reviews. Genetics · 2022Review
- Climate-responsive DNA methylation is involved in the biosynthesis of lignin in birch.Frontiers in plant science · 2022Article
- Comparative Genome Analysis of Genes Regulating Compound Inflorescences in Tomato.International journal of molecular sciences · 2021Article
- Review
- Comparative Physiological and Transcriptomic Analyses Reveal Altered Fe-Deficiency Responses in Tomato EpimutantFrontiers in plant science · 2021Article
- Epigenetics and epigenomics: underlying mechanisms, relevance, and implications in crop improvement.Functional & integrative genomics · 2020Review
- Article
- An RNAi suppressor activates in planta virus-mediated gene editing.Functional & integrative genomics · 2020Article
- Molecular and functional characterization of the SBP-box transcription factor SPL-CNR in tomato fruit ripening and cell death.Journal of experimental botany · 2020Article
- Natural variation in DNA methylation homeostasis and the emergence of epialleles.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
27 authors at 6 institutions in 3 countries.
Funding
Abstract
Naturally-occurring epimutants are rare and have mainly been described in plants. However how these mutants maintain their epigenetic marks and how they are inherited remain unknown. Here we report that CHROMOMETHYLASE3 (SlCMT3) and other methyltransferases are required for maintenance of a spontaneous epimutation and its cognate Colourless non-ripening (Cnr) phenotype in tomato. We screened a series of DNA methylation-related genes that could rescue the hypermethylated Cnr mutant. Silencing of the developmentally-regulated SlCMT3 gene results in increased expression of LeSPL-CNR, the gene encodes the SBP-box transcription factor residing at the Cnr locus and triggers Cnr fruits to ripen normally. Expression of other key ripening-genes was also up-regulated. Targeted and whole-genome bisulfite sequencing showed that the induced ripening of Cnr fruits is associated with reduction of methylation at CHG sites in a 286-bp region of the LeSPL-CNR promoter, and a decrease of DNA methylation in differentially-methylated regions associated with the LeMADS-RIN binding sites. Our results indicate that there is likely a concerted effect of different methyltransferases at the Cnr locus and the plant-specific SlCMT3 is essential for sustaining Cnr epi-allele. Maintenance of DNA methylation dynamics is critical for the somatic stability of Cnr epimutation and for the inheritance of tomato non-ripening phenotype.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.