ArticleBiological trace element research2015
The Effect of Cerium Oxide Nanoparticle Valence State on Reactive Oxygen Species and Toxicity.
Article in Biological trace element research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed.
- Ceria-Based Nanotherapeutics for Inflammatory Skin Disorders: From Design and Mechanisms to Advanced Delivery and Future Perspectives.International journal of molecular sciences · 2026Review
- Advances in the Rational Design, Mechanisms, and Applications of Lanthanide Nanoparticles for the Regulation of Reactive Oxygen Species.International journal of nanomedicine · 2026Review
- Ecofriendly algal extracellular polymeric substance-based nanobiocomposite for photodegradation of bisphenol A.iScience · 2025Article
- Bacterial membrane-modified cerium oxide nanoboosters enhance systemic antitumor effects of radiotherapy in metastatic triple-negative breast cancer.Journal of nanobiotechnology · 2025Article
- The effect of intra spinal administration of cerium oxide nanoparticles on central pain mechanism: An experimental study.Journal of bioenergetics and biomembranes · 2024Article
- Gadolinium Doping Modulates the Enzyme-like Activity and Radical-Scavenging Properties of CeONanomaterials (Basel, Switzerland) · 2024Article
- Protective Effects of Nanoceria against Mitochondrial Dysfunction and Angiotensin II-Induced Hypertrophy in H9c2 Cardiomyoblasts.Antioxidants (Basel, Switzerland) · 2023Article
- Prussian Blue Scavenger Ameliorates Hepatic Ischemia-Reperfusion Injury by Inhibiting Inflammation and Reducing Oxidative Stress.Frontiers in immunology · 2022Article
- Catalytic wet peroxide degradation of acrylonitrile wastewater by ordered mesoporous Ag/CeORSC advances · 2021Article
- A Stereological Study of the Toxic Effects of Cerium Oxide during Pregnancy on Kidney Tissues in Neonatal NMRI Mice.Oxidative medicine and cellular longevity · 2020Article
- Antioxidant activity of cerium dioxide nanoparticles and nanorods in scavenging hydroxyl radicals.RSC advances · 2019Article
- Approaches for the quantitative analysis of oxidation state in cerium oxide nanomaterials.Nanotechnology · 2019Article
- VariableFrontiers in pharmacology · 2019Article
- Cerium oxide nanoparticles with antioxidant capabilities and gadolinium integration for MRI contrast enhancement.Scientific reports · 2018Article
- Cerium oxide nanoparticles in neuroprotection and considerations for efficacy and safety.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2017Review
- Preparation and Biocompatible Surface Modification of Redox Altered Cerium Oxide Nanoparticle Promising for Nanobiology and Medicine.Bioengineering (Basel, Switzerland) · 2016Article
- Evaluation of the effect of valence state on cerium oxide nanoparticle toxicity following intratracheal instillation in rats.Nanotoxicology · 2016Article
- Direct stimulation of human fibroblasts by nCeO2 in vitro is attenuated with an amorphous silica coating.Particle and fibre toxicology · 2016Article
- Cerium Dioxide Nanoparticle Exposure Improves Microvascular Dysfunction and Reduces Oxidative Stress in Spontaneously Hypertensive Rats.Frontiers in physiology · 2015Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Cerium oxide (CeO2) nanoparticles, which are used in a variety of products including solar cells, gas sensors, and catalysts, are expected to increase in industrial use. This will subsequently lead to additional occupational exposures, making toxicology screenings crucial. Previous toxicology studies have presented conflicting results as to the extent of CeO2 toxicity, which is hypothesized to be due to the ability of Ce to exist in both a +3 and +4 valence state. Thus, to study whether valence state and oxygen vacancy concentration are important in CeO2 toxicity, CeO2 nanoparticles were doped with gadolinium to adjust the cation (Ce, Gd) and anion (O) defect states. The hypothesis that doping would increase toxicity and decrease antioxidant abilities as a result of increased oxygen vacancies and inhibition of +3 to +4 transition was tested. Differences in toxicity and reactivity based on valence state were determined in RLE-6TN rat alveolar epithelial and NR8383 rat alveolar macrophage cells using enhanced dark field microscopy, electron paramagnetic resonance (EPR), and annexin V/propidium iodide cell viability stain. Results from EPR indicated that as doping increased, antioxidant potential decreased. Alternatively, doping had no effect on toxicity at 24 h. The present results imply that as doping increases, thus subsequently increasing the Ce(3+)/Ce(4+) ratio, antioxidant potential decreases, suggesting that differences in reactivity of CeO2 are due to the ability of Ce to transition between the two valence states and the presence of increased oxygen vacancies, rather than dependent on a specific valence state.
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