ArticleNature2015
Shape-changing magnetic assemblies as high-sensitivity NMR-readable nanoprobes.
Article in Nature, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 61 citations in OpenAlex.
- Quantitative, high-sensitivity measurement of liquid analytes using a smartphone compass.Nature communications · 2024Article
- Direct observation of NMR transverse relaxation in nanopatterned clusters of iron oxide particles.Magnetic resonance in medicine · 2024Article
- Using Dissipative Particle Dynamics to Model Effects of Chemical Reactions Occurring within Hydrogels.Nanomaterials (Basel, Switzerland) · 2021Article
- Collagen- and hyaluronic acid-based hydrogels and their biomedical applications.Materials science & engineering. R, Reports : a review journal · 2021Article
- Multifield and inverse-contrast switching of magnetocaloric high contrast ratio MRI labels.Magnetic resonance in medicine · 2021Article
- Soft Capsule Magnetic Millirobots for Region-Specific Drug Delivery in the Central Nervous System.Frontiers in robotics and AI · 2021Article
- Spatiotemporally Controlled Photoresponsive Hydrogels: Design and Predictive Modeling from Processing through Application.Advanced functional materials · 2020Review
- Non-equilibrium signal integration in hydrogels.Nature communications · 2020Article
- Magnetic Microdevices for MRI-Based Detection of SARS-CoV-2 Viruses.IEEE open journal of engineering in medicine and biology · 2020Article
- Patterned Surface Energy in Elastomeric Molds as a Generalized Approach to Polymer Particle Fabrication.ACS applied polymer materials · 2020Article
- Assessment of the VDW interaction converting DMAPS from the thermal-motion form to the hydrogen-bonded form.Scientific reports · 2019Article
- Recent Developments in Nanosensors for Imaging Applications in Biological Systems.Annual review of analytical chemistry (Palo Alto, Calif.) · 2019Review
- Highly Sensitive and Selective Nanogap-Enhanced SERS Sensing Platform.Nanomaterials (Basel, Switzerland) · 2019Article
- Magnetocaloric materials as switchable high contrast ratio MRI labels.Magnetic resonance in medicine · 2019Article
- Acoustically modulated magnetic resonance imaging of gas-filled protein nanostructures.Nature materials · 2018Article
- Quantifying MRI frequency shifts due to structures with anisotropic magnetic susceptibility using pyrolytic graphite sheet.Scientific reports · 2018Article
- Hydrogels-Assisted Cell Engraftment for Repairing the Stroke-Damaged Brain: Chimera or Reality.Polymers · 2018Review
- Ferromagnetic particles as magnetic resonance imaging temperature sensors.Nature communications · 2016Article
- A high-resolution strain-gauge nanolaser.Nature communications · 2016Article
- DNA-gadolinium-gold nanoparticles for in vivo T1 MR imaging of transplanted human neural stem cells.Biomaterials · 2016Article
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
Fluorescent and plasmonic labels and sensors have revolutionized molecular biology, helping visualize cellular and biomolecular processes. Increasingly, such probes are now being designed to respond to wavelengths in the near-infrared region, where reduced tissue autofluorescence and photon attenuation enable subsurface in vivo sensing. But even in the near-infrared region, optical resolution and sensitivity decrease rapidly with increasing depth. Here we present a sensor design that obviates the need for optical addressability by operating in the nuclear magnetic resonance (NMR) radio-frequency spectrum, where signal attenuation and distortion by tissue and biological media are negligible, where background interferences vanish, and where sensors can be spatially located using standard magnetic resonance imaging (MRI) equipment. The radio-frequency-addressable sensor assemblies presented here comprise pairs of magnetic disks spaced by swellable hydrogel material; they reversibly reconfigure in rapid response to chosen stimuli, to give geometry-dependent, dynamic NMR spectral signatures. The sensors can be made from biocompatible materials, are themselves detectable down to low concentrations, and offer potential responsive NMR spectral shifts that are close to a million times greater than those of traditional magnetic resonance spectroscopies. Inherent adaptability should allow such shape-changing systems to measure numerous different environmental and physiological indicators, thus providing broadly generalizable, MRI-compatible, radio-frequency analogues to optically based probes for use in basic chemical, biological, medical and engineering research.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.