ArticleScientific reports2015
Intergenerational continuity of cell shape dynamics in Caulobacter crescentus.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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Who cites it
13 citing papers in PubMed.
- Mechanics ofMolecular biology of the cell · 2025Article
- Gene expression cycles drive non-exponential bacterial growth.Physical review research · 2025Article
- Coupling of cell growth modulation to asymmetric division and cell cycle regulation inProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Differential growth regulates asymmetric size partitioning inLife science alliance · 2024Article
- Scaling of stochastic growth and division dynamics: A comparative study of individual rod-shaped cells in the Mother Machine and SChemostat platforms.Molecular biology of the cell · 2024Article
- Super-exponential growth and stochastic size dynamics in rod-like bacteria.Biophysical journal · 2023Article
- Cellular resource allocation strategies for cell size and shape control in bacteria.The FEBS journal · 2022Review
- Selective sequestration of signalling proteins in a membraneless organelle reinforces the spatial regulation of asymmetry in Caulobacter crescentus.Nature microbiology · 2020Article
- Microfluidic time-lapse analysis and reevaluation of the Bacillus subtilis cell cycle.MicrobiologyOpen · 2019Article
- Article
- Motile curved bacteria are Pareto-optimal.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- High-resolution 3D models of Caulobacter crescentus chromosome reveal genome structural variability and organization.Nucleic acids research · 2018Article
- Biphasic growth dynamics control cell division in Caulobacter crescentus.Nature microbiology · 2017Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
We investigate the intergenerational shape dynamics of single Caulobacter crescentus cells using a novel combination of imaging techniques and theoretical modeling. We determine the dynamics of cell pole-to-pole lengths, cross-sectional widths, and medial curvatures from high accuracy measurements of cell contours. Moreover, these shape parameters are determined for over 250 cells across approximately 10000 total generations, which affords high statistical precision. Our data and model show that constriction is initiated early in the cell cycle and that its dynamics are controlled by the time scale of exponential longitudinal growth. Based on our extensive and detailed growth and contour data, we develop a minimal mechanical model that quantitatively accounts for the cell shape dynamics and suggests that the asymmetric location of the division plane reflects the distinct mechanical properties of the stalked and swarmer poles. Furthermore, we find that the asymmetry in the division plane location is inherited from the previous generation. We interpret these results in terms of the current molecular understanding of shape, growth, and division of C. crescentus.
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Registered trials
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